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A Case of Livedoid Vasculopathy Successfully Treated with Sulodexide
We report a 29-year-old female with a one-month history of non-healing multiple erythematous to violaceous plaques with crusts over both legs and feet. Tender, scarring ulcers with surrounding erythema were present. The clinical manifestation, together with histopathologic findings of fibrinoid plug...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Dermatological Association; The Korean Society for Investigative Dermatology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875231/ https://www.ncbi.nlm.nih.gov/pubmed/33911794 http://dx.doi.org/10.5021/ad.2020.32.6.508 |
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author | Song, Chang Hwa Shin, Dong Seok Jang, Ju Wang Kim, Tae Lim Kim, Young Gyun Kim, Joung Soo Seo, Hyun-Min |
author_facet | Song, Chang Hwa Shin, Dong Seok Jang, Ju Wang Kim, Tae Lim Kim, Young Gyun Kim, Joung Soo Seo, Hyun-Min |
author_sort | Song, Chang Hwa |
collection | PubMed |
description | We report a 29-year-old female with a one-month history of non-healing multiple erythematous to violaceous plaques with crusts over both legs and feet. Tender, scarring ulcers with surrounding erythema were present. The clinical manifestation, together with histopathologic findings of fibrinoid plugs within vascular lumens and walls, as well as red blood cell extravasation, led to diagnosis of livedoid vasculopathy. The patient experienced recurrent painful violaceous plaques with ulcerations during the two years of treatment with oral pentoxifylline 400 mg three times daily. The cutaneous lesions and symptoms dramatically improved after the treatment regimen changed to oral sulodexide (250 lipasemic units) three times daily. Sulodexide, a highly purified mixture of glycosaminoglycans including dermatan sulfate and low-molecular weight heparin, could be an effective therapy for recalcitrant livedoid vasculopathy. Herein, we report a case of livedoid vasculopathy treated with sulodexide, which has not previously been reported. |
format | Online Article Text |
id | pubmed-7875231 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Korean Dermatological Association; The Korean Society for Investigative Dermatology |
record_format | MEDLINE/PubMed |
spelling | pubmed-78752312021-04-27 A Case of Livedoid Vasculopathy Successfully Treated with Sulodexide Song, Chang Hwa Shin, Dong Seok Jang, Ju Wang Kim, Tae Lim Kim, Young Gyun Kim, Joung Soo Seo, Hyun-Min Ann Dermatol Case Report We report a 29-year-old female with a one-month history of non-healing multiple erythematous to violaceous plaques with crusts over both legs and feet. Tender, scarring ulcers with surrounding erythema were present. The clinical manifestation, together with histopathologic findings of fibrinoid plugs within vascular lumens and walls, as well as red blood cell extravasation, led to diagnosis of livedoid vasculopathy. The patient experienced recurrent painful violaceous plaques with ulcerations during the two years of treatment with oral pentoxifylline 400 mg three times daily. The cutaneous lesions and symptoms dramatically improved after the treatment regimen changed to oral sulodexide (250 lipasemic units) three times daily. Sulodexide, a highly purified mixture of glycosaminoglycans including dermatan sulfate and low-molecular weight heparin, could be an effective therapy for recalcitrant livedoid vasculopathy. Herein, we report a case of livedoid vasculopathy treated with sulodexide, which has not previously been reported. The Korean Dermatological Association; The Korean Society for Investigative Dermatology 2020-12 2020-11-11 /pmc/articles/PMC7875231/ /pubmed/33911794 http://dx.doi.org/10.5021/ad.2020.32.6.508 Text en Copyright © 2020 The Korean Dermatological Association and The Korean Society for Investigative Dermatology http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Song, Chang Hwa Shin, Dong Seok Jang, Ju Wang Kim, Tae Lim Kim, Young Gyun Kim, Joung Soo Seo, Hyun-Min A Case of Livedoid Vasculopathy Successfully Treated with Sulodexide |
title | A Case of Livedoid Vasculopathy Successfully Treated with Sulodexide |
title_full | A Case of Livedoid Vasculopathy Successfully Treated with Sulodexide |
title_fullStr | A Case of Livedoid Vasculopathy Successfully Treated with Sulodexide |
title_full_unstemmed | A Case of Livedoid Vasculopathy Successfully Treated with Sulodexide |
title_short | A Case of Livedoid Vasculopathy Successfully Treated with Sulodexide |
title_sort | case of livedoid vasculopathy successfully treated with sulodexide |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875231/ https://www.ncbi.nlm.nih.gov/pubmed/33911794 http://dx.doi.org/10.5021/ad.2020.32.6.508 |
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