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Estimating the time-varying reproduction number of COVID-19 with a state-space method

After slowing down the spread of the novel coronavirus COVID-19, many countries have started to relax their confinement measures in the face of critical damage to socioeconomic structures. At this stage, it is desirable to monitor the degree to which political measures or social affairs have exerted...

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Detalles Bibliográficos
Autores principales: Koyama, Shinsuke, Horie, Taiki, Shinomoto, Shigeru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875393/
https://www.ncbi.nlm.nih.gov/pubmed/33513137
http://dx.doi.org/10.1371/journal.pcbi.1008679
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author Koyama, Shinsuke
Horie, Taiki
Shinomoto, Shigeru
author_facet Koyama, Shinsuke
Horie, Taiki
Shinomoto, Shigeru
author_sort Koyama, Shinsuke
collection PubMed
description After slowing down the spread of the novel coronavirus COVID-19, many countries have started to relax their confinement measures in the face of critical damage to socioeconomic structures. At this stage, it is desirable to monitor the degree to which political measures or social affairs have exerted influence on the spread of disease. Though it is difficult to trace back individual transmission of infections whose incubation periods are long and highly variable, estimating the average spreading rate is possible if a proper mathematical model can be devised to analyze daily event-occurrences. To render an accurate assessment, we have devised a state-space method for fitting a discrete-time variant of the Hawkes process to a given dataset of daily confirmed cases. The proposed method detects changes occurring in each country and assesses the impact of social events in terms of the temporally varying reproduction number, which corresponds to the average number of cases directly caused by a single infected case. Moreover, the proposed method can be used to predict the possible consequences of alternative political measures. This information can serve as a reference for behavioral guidelines that should be adopted according to the varying risk of infection.
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spelling pubmed-78753932021-02-19 Estimating the time-varying reproduction number of COVID-19 with a state-space method Koyama, Shinsuke Horie, Taiki Shinomoto, Shigeru PLoS Comput Biol Research Article After slowing down the spread of the novel coronavirus COVID-19, many countries have started to relax their confinement measures in the face of critical damage to socioeconomic structures. At this stage, it is desirable to monitor the degree to which political measures or social affairs have exerted influence on the spread of disease. Though it is difficult to trace back individual transmission of infections whose incubation periods are long and highly variable, estimating the average spreading rate is possible if a proper mathematical model can be devised to analyze daily event-occurrences. To render an accurate assessment, we have devised a state-space method for fitting a discrete-time variant of the Hawkes process to a given dataset of daily confirmed cases. The proposed method detects changes occurring in each country and assesses the impact of social events in terms of the temporally varying reproduction number, which corresponds to the average number of cases directly caused by a single infected case. Moreover, the proposed method can be used to predict the possible consequences of alternative political measures. This information can serve as a reference for behavioral guidelines that should be adopted according to the varying risk of infection. Public Library of Science 2021-01-29 /pmc/articles/PMC7875393/ /pubmed/33513137 http://dx.doi.org/10.1371/journal.pcbi.1008679 Text en © 2021 Koyama et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Koyama, Shinsuke
Horie, Taiki
Shinomoto, Shigeru
Estimating the time-varying reproduction number of COVID-19 with a state-space method
title Estimating the time-varying reproduction number of COVID-19 with a state-space method
title_full Estimating the time-varying reproduction number of COVID-19 with a state-space method
title_fullStr Estimating the time-varying reproduction number of COVID-19 with a state-space method
title_full_unstemmed Estimating the time-varying reproduction number of COVID-19 with a state-space method
title_short Estimating the time-varying reproduction number of COVID-19 with a state-space method
title_sort estimating the time-varying reproduction number of covid-19 with a state-space method
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875393/
https://www.ncbi.nlm.nih.gov/pubmed/33513137
http://dx.doi.org/10.1371/journal.pcbi.1008679
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