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Genome-scale CRISPR screening for modifiers of cellular LDL uptake

Hypercholesterolemia is a causal and modifiable risk factor for atherosclerotic cardiovascular disease. A critical pathway regulating cholesterol homeostasis involves the receptor-mediated endocytosis of low-density lipoproteins into hepatocytes, mediated by the LDL receptor. We applied genome-scale...

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Detalles Bibliográficos
Autores principales:	Emmer, Brian T., Sherman, Emily J., Lascuna, Paul J., Graham, Sarah E., Willer, Cristen J., Ginsburg, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875399/ https://www.ncbi.nlm.nih.gov/pubmed/33513160 http://dx.doi.org/10.1371/journal.pgen.1009285

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