Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer

The lipogenic enzyme stearoyl CoA desaturase (SCD) plays a key role in tumor lipid metabolism and membrane architecture. SCD is often up-regulated and a therapeutic target in cancer. Here, we report the unexpected finding that median expression of SCD is low in glioblastoma relative to normal brain...

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Detalles Bibliográficos
Autores principales: Oatman, Nicole, Dasgupta, Nupur, Arora, Priyanka, Choi, Kwangmin, Gawali, Mruniya V., Gupta, Nishtha, Parameswaran, Sreeja, Salomone, Joseph, Reisz, Julie A., Lawler, Sean, Furnari, Frank, Brennan, Cameron, Wu, Jianqiang, Sallans, Larry, Gudelsky, Gary, Desai, Pankaj, Gebelein, Brian, Weirauch, Matthew T., D’Alessandro, Angelo, Komurov, Kakajan, Dasgupta, Biplab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875532/
https://www.ncbi.nlm.nih.gov/pubmed/33568479
http://dx.doi.org/10.1126/sciadv.abd7459

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