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Overexpression of GSE1 Related to Trastuzumab Resistance in Gastric Cancer Cells

Gastric cancer is one of the most prevalent human cancers with poor prognosis. Trastuzumab is a well-used targeted drug for gastric cancer with HER2 amplification. Trastuzumab resistance restrains the clinical use of trastuzumab. In this study, we reported human Gse1 coiled-coil protein (GSE1) promo...

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Detalles Bibliográficos
Autores principales: Wang, Wenbin, Wang, Shuanhu, Xu, A. man, Yuan, Xiao, Huang, Liguo, Li, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875631/
https://www.ncbi.nlm.nih.gov/pubmed/33623790
http://dx.doi.org/10.1155/2021/8834923
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author Wang, Wenbin
Wang, Shuanhu
Xu, A. man
Yuan, Xiao
Huang, Liguo
Li, Jun
author_facet Wang, Wenbin
Wang, Shuanhu
Xu, A. man
Yuan, Xiao
Huang, Liguo
Li, Jun
author_sort Wang, Wenbin
collection PubMed
description Gastric cancer is one of the most prevalent human cancers with poor prognosis. Trastuzumab is a well-used targeted drug for gastric cancer with HER2 amplification. Trastuzumab resistance restrains the clinical use of trastuzumab. In this study, we reported human Gse1 coiled-coil protein (GSE1) promoted trastuzumab resistance in HER2-positive gastric cancer cells. Acquired trastuzumab-resistant gastric cancer cells overexpressed GSE1, and depletion of GSE1 decreased the trastuzumab resistance of trastuzumab-resistant gastric cancer cells. BCL-2 was a downstream gene positively regulated by GSE1 and also performed promoting the role of trastuzumab resistance in HER2-positive gastric cancer cells. A high level of GSE1 was associated with a high risk of tumor lymph node metastasis and higher clinical stage in HER2-positive gastric cancer patients. GSE1 was a potential target that could be used for HER2-positive gastric cancer therapy.
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spelling pubmed-78756312021-02-22 Overexpression of GSE1 Related to Trastuzumab Resistance in Gastric Cancer Cells Wang, Wenbin Wang, Shuanhu Xu, A. man Yuan, Xiao Huang, Liguo Li, Jun Biomed Res Int Research Article Gastric cancer is one of the most prevalent human cancers with poor prognosis. Trastuzumab is a well-used targeted drug for gastric cancer with HER2 amplification. Trastuzumab resistance restrains the clinical use of trastuzumab. In this study, we reported human Gse1 coiled-coil protein (GSE1) promoted trastuzumab resistance in HER2-positive gastric cancer cells. Acquired trastuzumab-resistant gastric cancer cells overexpressed GSE1, and depletion of GSE1 decreased the trastuzumab resistance of trastuzumab-resistant gastric cancer cells. BCL-2 was a downstream gene positively regulated by GSE1 and also performed promoting the role of trastuzumab resistance in HER2-positive gastric cancer cells. A high level of GSE1 was associated with a high risk of tumor lymph node metastasis and higher clinical stage in HER2-positive gastric cancer patients. GSE1 was a potential target that could be used for HER2-positive gastric cancer therapy. Hindawi 2021-02-02 /pmc/articles/PMC7875631/ /pubmed/33623790 http://dx.doi.org/10.1155/2021/8834923 Text en Copyright © 2021 Wenbin Wang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Wenbin
Wang, Shuanhu
Xu, A. man
Yuan, Xiao
Huang, Liguo
Li, Jun
Overexpression of GSE1 Related to Trastuzumab Resistance in Gastric Cancer Cells
title Overexpression of GSE1 Related to Trastuzumab Resistance in Gastric Cancer Cells
title_full Overexpression of GSE1 Related to Trastuzumab Resistance in Gastric Cancer Cells
title_fullStr Overexpression of GSE1 Related to Trastuzumab Resistance in Gastric Cancer Cells
title_full_unstemmed Overexpression of GSE1 Related to Trastuzumab Resistance in Gastric Cancer Cells
title_short Overexpression of GSE1 Related to Trastuzumab Resistance in Gastric Cancer Cells
title_sort overexpression of gse1 related to trastuzumab resistance in gastric cancer cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875631/
https://www.ncbi.nlm.nih.gov/pubmed/33623790
http://dx.doi.org/10.1155/2021/8834923
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