Elucidation of the Hdac2/Sp1/miR-204-5p/Bcl-2 axis as a modulator of cochlear apoptosis via in vivo/in vitro models of acute hearing loss

We previously reported that dysregulation of histone deacetylase 2 (Hdac2) was associated with the prognosis of sudden sensorineural hearing loss. However, the underlying molecular mechanisms are poorly understood. In the present study, we developed an acute hearing loss animal model in guinea pigs...

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Detalles Bibliográficos
Autores principales: Xie, Lisheng, Zhou, Qiongqiong, Chen, Xiaorui, Du, Xiaoping, Liu, Zhibiao, Fei, Bing, Hou, Jie, Dai, Yanhong, She, Wandong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875768/
https://www.ncbi.nlm.nih.gov/pubmed/33614251
http://dx.doi.org/10.1016/j.omtn.2021.01.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875768/
https://www.ncbi.nlm.nih.gov/pubmed/33614251
http://dx.doi.org/10.1016/j.omtn.2021.01.017

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