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Spider Venom Peptide Pn3a Inhibition of Primary Afferent High Voltage-Activated Calcium Channels
Despite potently inhibiting the nociceptive voltage-gated sodium (Na(v)) channel, Na(v)1.7, µ-theraphotoxin Pn3a is antinociceptive only upon co-administration with sub-therapeutic opioid agonists, or by itself at doses >3,000-fold greater than its Na(v)1.7 IC (50) by a yet undefined mechanism. N...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875911/ https://www.ncbi.nlm.nih.gov/pubmed/33584315 http://dx.doi.org/10.3389/fphar.2020.633679 |