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Role of PDK1 in skeletal muscle hypertrophy induced by mechanical load

Phosphatidylinositol 3-kinase (PI3K) plays an important role in protein metabolism and cell growth. We here show that mice (M-PDK1KO mice) with skeletal muscle–specific deficiency of 3′-phosphoinositide–dependent kinase 1 (PDK1), a key component of PI3K signaling pathway, manifest a reduced skeletal...

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Detalles Bibliográficos
Autores principales:	Kuramoto, Naoki, Nomura, Kazuhiro, Kohno, Daisuke, Kitamura, Tadahiro, Karsenty, Gerard, Hosooka, Tetsuya, Ogawa, Wataru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876046/ https://www.ncbi.nlm.nih.gov/pubmed/33568757 http://dx.doi.org/10.1038/s41598-021-83098-z

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