Cargando…

An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo

Lipid peroxidation-initiated ferroptosis is an iron-dependent mechanism of programmed cell death taking place in neurological diseases. Here we show that a condensed benzo[b]thiazine derivative small molecule with an arylthiazine backbone (ADA-409-052) inhibits tert-Butyl hydroperoxide (TBHP)-induce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Keuters, Meike Hedwig, Keksa-Goldsteine, Velta, Dhungana, Hiramani, Huuskonen, Mikko T., Pomeshchik, Yuriy, Savchenko, Ekaterina, Korhonen, Paula K., Singh, Yajuvinder, Wojciechowski, Sara, Lehtonen, Šárka, Kanninen, Katja M., Malm, Tarja, Sirviö, Jouni, Muona, Anu, Koistinaho, Milla, Goldsteins, Gundars, Koistinaho, Jari
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876050/ https://www.ncbi.nlm.nih.gov/pubmed/33568697 http://dx.doi.org/10.1038/s41598-021-81741-3

Ejemplares similares

Peripheral Administration of IL-13 Induces Anti-inflammatory Microglial/Macrophage Responses and Provides Neuroprotection in Ischemic Stroke
por: Kolosowska, Natalia, et al.
Publicado: (2019)

Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation
por: Dhungana, Hiramani, et al.
Publicado: (2017)

Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy
por: Huuskonen, Mikko T., et al.
Publicado: (2016)

Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes
por: Liddell, Jeffrey R., et al.
Publicado: (2016)

CNS Redox Homeostasis and Dysfunction in Neurodegenerative Diseases
por: Goldsteins, Gundars, et al.
Publicado: (2022)

Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis
por: Korhonen, Paula, et al.
Publicado: (2019)

Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy
por: Leinonen, Henri, et al.
Publicado: (2017)

ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
por: Lemarchant, Sighild, et al.
Publicado: (2016)

Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
por: Lemarchant, Sighild, et al.
Publicado: (2016)

Dysfunction of Cellular Proteostasis in Parkinson’s Disease
por: Lehtonen, Šárka, et al.
Publicado: (2019)

Loss of Cln5 causes altered neurogenesis in a mouse model of a childhood neurodegenerative disorder
por: Savchenko, Ekaterina, et al.
Publicado: (2017)

Glycogen Synthase Kinase-3β: A Mediator of Inflammation in Alzheimer's Disease?
por: Koistinaho, Jari, et al.
Publicado: (2011)

Proteostasis Disturbances and Inflammation in Neurodegenerative Diseases
por: Sonninen, Tuuli-Maria, et al.
Publicado: (2020)

Human intravenous immunoglobulin provides protection against Aβ toxicity by multiple mechanisms in a mouse model of Alzheimer's disease
por: Magga, Johanna, et al.
Publicado: (2010)

Granulocyte colony stimulating factor attenuates inflammation in a mouse model of amyotrophic lateral sclerosis
por: Pollari, Eveliina, et al.
Publicado: (2011)

Lack of collagen XV is protective after ischemic stroke in mice
por: Dhungana, Hiramani, et al.
Publicado: (2017)

Astrocyte alterations in neurodegenerative pathologies and their modeling in human induced pluripotent stem cell platforms
por: Oksanen, Minna, et al.
Publicado: (2019)

Production of monocytic cells from bone marrow stem cells: therapeutic usage in Alzheimer’s disease
por: Magga, Johanna, et al.
Publicado: (2012)

Mechanisms of mutant SOD1 induced mitochondrial toxicity in amyotrophic lateral sclerosis
por: Vehviläinen, Piia, et al.
Publicado: (2014)

ER stress and unfolded protein response in amyotrophic lateral sclerosis—a controversial role of protein disulphide isomerase
por: Jaronen, Merja, et al.
Publicado: (2014)

Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele
por: Dhungana, Hiramani, et al.
Publicado: (2013)

The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis
por: Pollari, Eveliina, et al.
Publicado: (2014)

Metabolic alterations in Parkinson’s disease astrocytes
por: Sonninen, Tuuli-Maria, et al.
Publicado: (2020)

Utilization of APPswe/PS1dE9 Transgenic Mice in Research of Alzheimer's Disease: Focus on Gene Therapy and Cell-Based Therapy Applications
por: Malm, Tarja, et al.
Publicado: (2011)

Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation
por: Kolosowska, Natalia, et al.
Publicado: (2020)

Effects of human intravenous immunoglobulin on amyloid pathology and neuroinflammation in a mouse model of Alzheimer’s disease
por: Puli, Lakshman, et al.
Publicado: (2012)

Targeting Glycogen Synthase Kinase-3β for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease: Involvement of the Nrf2-ARE Pathway
por: Kanninen, Katja, et al.
Publicado: (2011)

Developmental Dysfunction of the Central Nervous System Lymphatics Modulates the Adaptive Neuro-Immune Response in the Perilesional Cortex in a Mouse Model of Traumatic Brain Injury
por: Wojciechowski, Sara, et al.
Publicado: (2021)

Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation
por: Byts, Nadiya, et al.
Publicado: (2022)

Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice
por: Jäntti, Henna, et al.
Publicado: (2022)

Aβ and Inflammatory Stimulus Activate Diverse Signaling Pathways in Monocytic Cells: Implications in Retaining Phagocytosis in Aβ-Laden Environment
por: Savchenko, Ekaterina, et al.
Publicado: (2016)

Blood–Brain Barrier and Neurodegenerative Diseases—Modeling with iPSC-Derived Brain Cells
por: Wu, Ying-Chieh, et al.
Publicado: (2021)

NF‐E2‐related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin‐1 mutated Alzheimer's disease astrocytes
por: Oksanen, Minna, et al.
Publicado: (2019)

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death
por: Martiskainen, Henna, et al.
Publicado: (2017)

Perineuronal nets in neurodegeneration
por: Lemarchant, Sighild, et al.
Publicado: (2016)

Animal Models of Alzheimer’s Disease: Utilization of Transgenic Alzheimer’s Disease Models in Studies of Amyloid Beta Clearance
por: Malm, Tarja, et al.
Publicado: (2012)

Structural Immaturity of Human iPSC-Derived Cardiomyocytes: In Silico Investigation of Effects on Function and Disease Modeling
por: Koivumäki, Jussi T., et al.
Publicado: (2018)

Biometals in rare neurodegenerative disorders of childhood
por: Parker, Sarah J., et al.
Publicado: (2013)

A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke
por: Maysami, Samaneh, et al.
Publicado: (2015)

Contribution of astrocytes to familial risk and clinical manifestation of schizophrenia
por: Koskuvi, Marja, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ik064bpijl9t5ghjver871jlvb