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Resting-State Cerebello-Cortical Dysfunction in Parkinson's Disease

Purpose: Recently, the cerebellum's role in Parkinson's disease (PD) has been highlighted. Therefore, this study sought to test the hypothesis that functional connectivity (FC) between cerebellar and cortical nodes of the resting-state networks differentiates PD patients from controls by s...

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Autores principales: Palmer, William C., Cholerton, Brenna A., Zabetian, Cyrus P., Montine, Thomas J., Grabowski, Thomas J., Rane, Swati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876057/
https://www.ncbi.nlm.nih.gov/pubmed/33584497
http://dx.doi.org/10.3389/fneur.2020.594213
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author Palmer, William C.
Cholerton, Brenna A.
Zabetian, Cyrus P.
Montine, Thomas J.
Grabowski, Thomas J.
Rane, Swati
author_facet Palmer, William C.
Cholerton, Brenna A.
Zabetian, Cyrus P.
Montine, Thomas J.
Grabowski, Thomas J.
Rane, Swati
author_sort Palmer, William C.
collection PubMed
description Purpose: Recently, the cerebellum's role in Parkinson's disease (PD) has been highlighted. Therefore, this study sought to test the hypothesis that functional connectivity (FC) between cerebellar and cortical nodes of the resting-state networks differentiates PD patients from controls by scanning participants at rest using functional magnetic resonance imaging (fMRI) and investigating connectivity of the cerebellar nodes of the resting-state networks. Materials and Methods: Sixty-two PD participants off medication for at least 12 h and 33 normal controls (NCs) were scanned at rest using blood oxygenation level-dependent fMRI scans. Motor and cognitive functions were assessed with the Movement Disorder Society's Revision of the Unified Parkinson's Disease Rating Scale III and Montreal Cognitive Assessment, respectively. Connectivity was investigated with cerebellar seeds defined by Buckner's 7-network atlas. Results: PD participants had significant differences in FC when compared to NC participants. Most notably, PD patients had higher FC between cerebellar nodes of the somatomotor network (SMN) and the corresponding cortical nodes. Cognitive functioning was differentially associated with connectivity of the cerebellar SMN and dorsal attention network. Further, cerebellar connectivity of frontoparietal and default mode networks correlated with the severity of motor function. Conclusion: Our study demonstrates altered cerebello-cortical FC in PD, as well as an association of this FC with PD-related motor and cognitive disruptions, thus providing additional evidence for the cerebellum's role in PD.
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spelling pubmed-78760572021-02-12 Resting-State Cerebello-Cortical Dysfunction in Parkinson's Disease Palmer, William C. Cholerton, Brenna A. Zabetian, Cyrus P. Montine, Thomas J. Grabowski, Thomas J. Rane, Swati Front Neurol Neurology Purpose: Recently, the cerebellum's role in Parkinson's disease (PD) has been highlighted. Therefore, this study sought to test the hypothesis that functional connectivity (FC) between cerebellar and cortical nodes of the resting-state networks differentiates PD patients from controls by scanning participants at rest using functional magnetic resonance imaging (fMRI) and investigating connectivity of the cerebellar nodes of the resting-state networks. Materials and Methods: Sixty-two PD participants off medication for at least 12 h and 33 normal controls (NCs) were scanned at rest using blood oxygenation level-dependent fMRI scans. Motor and cognitive functions were assessed with the Movement Disorder Society's Revision of the Unified Parkinson's Disease Rating Scale III and Montreal Cognitive Assessment, respectively. Connectivity was investigated with cerebellar seeds defined by Buckner's 7-network atlas. Results: PD participants had significant differences in FC when compared to NC participants. Most notably, PD patients had higher FC between cerebellar nodes of the somatomotor network (SMN) and the corresponding cortical nodes. Cognitive functioning was differentially associated with connectivity of the cerebellar SMN and dorsal attention network. Further, cerebellar connectivity of frontoparietal and default mode networks correlated with the severity of motor function. Conclusion: Our study demonstrates altered cerebello-cortical FC in PD, as well as an association of this FC with PD-related motor and cognitive disruptions, thus providing additional evidence for the cerebellum's role in PD. Frontiers Media S.A. 2021-01-28 /pmc/articles/PMC7876057/ /pubmed/33584497 http://dx.doi.org/10.3389/fneur.2020.594213 Text en Copyright © 2021 Palmer, Cholerton, Zabetian, Montine, Grabowski and Rane. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Palmer, William C.
Cholerton, Brenna A.
Zabetian, Cyrus P.
Montine, Thomas J.
Grabowski, Thomas J.
Rane, Swati
Resting-State Cerebello-Cortical Dysfunction in Parkinson's Disease
title Resting-State Cerebello-Cortical Dysfunction in Parkinson's Disease
title_full Resting-State Cerebello-Cortical Dysfunction in Parkinson's Disease
title_fullStr Resting-State Cerebello-Cortical Dysfunction in Parkinson's Disease
title_full_unstemmed Resting-State Cerebello-Cortical Dysfunction in Parkinson's Disease
title_short Resting-State Cerebello-Cortical Dysfunction in Parkinson's Disease
title_sort resting-state cerebello-cortical dysfunction in parkinson's disease
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876057/
https://www.ncbi.nlm.nih.gov/pubmed/33584497
http://dx.doi.org/10.3389/fneur.2020.594213
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