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Strongest Correlation Between Contrast Sensitivity and Morphological Characteristics in Bilateral nAMD

In patients with neovascular age-related macular degeneration (nAMD) there is often an inconsistency between their subjective visual impairment and a still relatively preserved standard Early Treatment of Diabetic Retinopathy Study (ETDRS) best corrected visual acuity. Therefore, in order to better...

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Autores principales: Hoffmann, Laura, Rossouw, Petra, Guichard, Maria-Magdalena, Hatz, Katja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876058/
https://www.ncbi.nlm.nih.gov/pubmed/33585517
http://dx.doi.org/10.3389/fmed.2020.622877
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author Hoffmann, Laura
Rossouw, Petra
Guichard, Maria-Magdalena
Hatz, Katja
author_facet Hoffmann, Laura
Rossouw, Petra
Guichard, Maria-Magdalena
Hatz, Katja
author_sort Hoffmann, Laura
collection PubMed
description In patients with neovascular age-related macular degeneration (nAMD) there is often an inconsistency between their subjective visual impairment and a still relatively preserved standard Early Treatment of Diabetic Retinopathy Study (ETDRS) best corrected visual acuity. Therefore, in order to better capture the specific functional defects in nAMD, other tests need to be evaluated. In a previous study, we reported contrast sensitivity of the better eye to best correlate with near distance and distance vision related quality of life in patients with bilateral nAMD. Here, we evaluated Pelli-Robson contrast sensitivity, ETDRS visual acuity, low luminance visual acuity and Radner maximum reading speed and correlated them with several morphologic parameters as measured on fundus autofluorescence imaging, optical coherence tomography and optical tomography angiography in 54 patients. A multiple regression analysis was performed which correlated each visual function parameter with the anatomic features. The results showed the strongest correlations between the total area of macular geographic atrophy as well as the percentage of geographic atrophy in the central 1 mm and contrast sensitivity. Further, the regression model selected the total area of macular geographic atrophy, the photoreceptor inner and outer segments interface disruption score, the presence of subretinal fibrosis in the central 1 mm and the central retinal thickness as the variables that explained 71% of the variation in contrast sensitivity when including all eyes. Hence, our results suggest that among the evaluated measures of vision, contrast sensitivity is best correlated with the morphologic impairment in bilateral nAMD. Thus, contrast sensitivity may complement ETDRS visual acuity in clinical trials and serve as a standard diagnostic tool in clinical practice.
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spelling pubmed-78760582021-02-12 Strongest Correlation Between Contrast Sensitivity and Morphological Characteristics in Bilateral nAMD Hoffmann, Laura Rossouw, Petra Guichard, Maria-Magdalena Hatz, Katja Front Med (Lausanne) Medicine In patients with neovascular age-related macular degeneration (nAMD) there is often an inconsistency between their subjective visual impairment and a still relatively preserved standard Early Treatment of Diabetic Retinopathy Study (ETDRS) best corrected visual acuity. Therefore, in order to better capture the specific functional defects in nAMD, other tests need to be evaluated. In a previous study, we reported contrast sensitivity of the better eye to best correlate with near distance and distance vision related quality of life in patients with bilateral nAMD. Here, we evaluated Pelli-Robson contrast sensitivity, ETDRS visual acuity, low luminance visual acuity and Radner maximum reading speed and correlated them with several morphologic parameters as measured on fundus autofluorescence imaging, optical coherence tomography and optical tomography angiography in 54 patients. A multiple regression analysis was performed which correlated each visual function parameter with the anatomic features. The results showed the strongest correlations between the total area of macular geographic atrophy as well as the percentage of geographic atrophy in the central 1 mm and contrast sensitivity. Further, the regression model selected the total area of macular geographic atrophy, the photoreceptor inner and outer segments interface disruption score, the presence of subretinal fibrosis in the central 1 mm and the central retinal thickness as the variables that explained 71% of the variation in contrast sensitivity when including all eyes. Hence, our results suggest that among the evaluated measures of vision, contrast sensitivity is best correlated with the morphologic impairment in bilateral nAMD. Thus, contrast sensitivity may complement ETDRS visual acuity in clinical trials and serve as a standard diagnostic tool in clinical practice. Frontiers Media S.A. 2021-01-28 /pmc/articles/PMC7876058/ /pubmed/33585517 http://dx.doi.org/10.3389/fmed.2020.622877 Text en Copyright © 2021 Hoffmann, Rossouw, Guichard and Hatz. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Hoffmann, Laura
Rossouw, Petra
Guichard, Maria-Magdalena
Hatz, Katja
Strongest Correlation Between Contrast Sensitivity and Morphological Characteristics in Bilateral nAMD
title Strongest Correlation Between Contrast Sensitivity and Morphological Characteristics in Bilateral nAMD
title_full Strongest Correlation Between Contrast Sensitivity and Morphological Characteristics in Bilateral nAMD
title_fullStr Strongest Correlation Between Contrast Sensitivity and Morphological Characteristics in Bilateral nAMD
title_full_unstemmed Strongest Correlation Between Contrast Sensitivity and Morphological Characteristics in Bilateral nAMD
title_short Strongest Correlation Between Contrast Sensitivity and Morphological Characteristics in Bilateral nAMD
title_sort strongest correlation between contrast sensitivity and morphological characteristics in bilateral namd
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876058/
https://www.ncbi.nlm.nih.gov/pubmed/33585517
http://dx.doi.org/10.3389/fmed.2020.622877
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