AKT1-CREB stimulation of PDGFRα expression is pivotal for PTEN deficient tumor development

As evidenced by the behavior of loss-of-function mutants of PTEN in the context of a gain-of-function mutation of AKT1, the PTEN-AKT1 signaling pathway plays a critical role in human cancers. In this study, we demonstrated that a deficiency in PTEN or activation of AKT1 potentiated the expression of...

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Detalles Bibliográficos
Autores principales: Wan, Xiaofeng, Zhou, Meng, Huang, Fuqiang, Zhao, Na, Chen, Xu, Wu, Yuncui, Zhu, Wanhui, Ni, Zhaofei, Jin, Fuquan, Wang, Yani, Hu, Zhongdong, Chen, Xianguo, Ren, Min, Zhang, Hongbing, Zha, Xiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876135/
https://www.ncbi.nlm.nih.gov/pubmed/33568640
http://dx.doi.org/10.1038/s41419-021-03433-0

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