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The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition

α-Synuclein (αS) is a presynaptic disordered protein whose aberrant aggregation is associated with Parkinson’s disease. The functional role of αS is still debated, although it has been involved in the regulation of neurotransmitter release via the interaction with synaptic vesicles (SVs). We report...

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Detalles Bibliográficos
Autores principales: Man, Wing K., Tahirbegi, Bogachan, Vrettas, Michail D., Preet, Swapan, Ying, Liming, Vendruscolo, Michele, De Simone, Alfonso, Fusco, Giuliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876145/
https://www.ncbi.nlm.nih.gov/pubmed/33568632
http://dx.doi.org/10.1038/s41467-021-21027-4