Cargando…

Ghrelin as an Anti-Sepsis Peptide: Review

Sepsis continues to produce widespread inflammation, illness, and death, prompting intensive research aimed at uncovering causes and therapies. In this article, we focus on ghrelin, an endogenous peptide with promise as a potent anti-inflammatory agent. Ghrelin was discovered, tracked, and isolated...

Descripción completa

Detalles Bibliográficos
Autores principales: Mathur, Nimisha, Mehdi, Syed F., Anipindi, Manasa, Aziz, Monowar, Khan, Sawleha A., Kondakindi, Hema, Lowell, Barbara, Wang, Ping, Roth, Jesse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876230/
https://www.ncbi.nlm.nih.gov/pubmed/33584688
http://dx.doi.org/10.3389/fimmu.2020.610363
_version_ 1783649927160659968
author Mathur, Nimisha
Mehdi, Syed F.
Anipindi, Manasa
Aziz, Monowar
Khan, Sawleha A.
Kondakindi, Hema
Lowell, Barbara
Wang, Ping
Roth, Jesse
author_facet Mathur, Nimisha
Mehdi, Syed F.
Anipindi, Manasa
Aziz, Monowar
Khan, Sawleha A.
Kondakindi, Hema
Lowell, Barbara
Wang, Ping
Roth, Jesse
author_sort Mathur, Nimisha
collection PubMed
description Sepsis continues to produce widespread inflammation, illness, and death, prompting intensive research aimed at uncovering causes and therapies. In this article, we focus on ghrelin, an endogenous peptide with promise as a potent anti-inflammatory agent. Ghrelin was discovered, tracked, and isolated from stomach cells based on its ability to stimulate release of growth hormone. It also stimulates appetite and is shown to be anti-inflammatory in a wide range of tissues. The anti-inflammatory effects mediated by ghrelin are a result of both the stimulation of anti-inflammatory processes and an inhibition of pro-inflammatory forces. Anti-inflammatory processes are promoted in a broad range of tissues including the hypothalamus and vagus nerve as well as in a broad range of immune cells. Aged rodents have reduced levels of growth hormone (GH) and diminished immune responses; ghrelin administration boosts GH levels and immune response. The anti-inflammatory functions of ghrelin, well displayed in preclinical animal models of sepsis, are just being charted in patients, with expectations that ghrelin and growth hormone might improve outcomes in patients with sepsis.
format Online
Article
Text
id pubmed-7876230
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-78762302021-02-12 Ghrelin as an Anti-Sepsis Peptide: Review Mathur, Nimisha Mehdi, Syed F. Anipindi, Manasa Aziz, Monowar Khan, Sawleha A. Kondakindi, Hema Lowell, Barbara Wang, Ping Roth, Jesse Front Immunol Immunology Sepsis continues to produce widespread inflammation, illness, and death, prompting intensive research aimed at uncovering causes and therapies. In this article, we focus on ghrelin, an endogenous peptide with promise as a potent anti-inflammatory agent. Ghrelin was discovered, tracked, and isolated from stomach cells based on its ability to stimulate release of growth hormone. It also stimulates appetite and is shown to be anti-inflammatory in a wide range of tissues. The anti-inflammatory effects mediated by ghrelin are a result of both the stimulation of anti-inflammatory processes and an inhibition of pro-inflammatory forces. Anti-inflammatory processes are promoted in a broad range of tissues including the hypothalamus and vagus nerve as well as in a broad range of immune cells. Aged rodents have reduced levels of growth hormone (GH) and diminished immune responses; ghrelin administration boosts GH levels and immune response. The anti-inflammatory functions of ghrelin, well displayed in preclinical animal models of sepsis, are just being charted in patients, with expectations that ghrelin and growth hormone might improve outcomes in patients with sepsis. Frontiers Media S.A. 2021-01-28 /pmc/articles/PMC7876230/ /pubmed/33584688 http://dx.doi.org/10.3389/fimmu.2020.610363 Text en Copyright © 2021 Mathur, Mehdi, Anipindi, Aziz, Khan, Kondakindi, Lowell, Wang and Roth http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Mathur, Nimisha
Mehdi, Syed F.
Anipindi, Manasa
Aziz, Monowar
Khan, Sawleha A.
Kondakindi, Hema
Lowell, Barbara
Wang, Ping
Roth, Jesse
Ghrelin as an Anti-Sepsis Peptide: Review
title Ghrelin as an Anti-Sepsis Peptide: Review
title_full Ghrelin as an Anti-Sepsis Peptide: Review
title_fullStr Ghrelin as an Anti-Sepsis Peptide: Review
title_full_unstemmed Ghrelin as an Anti-Sepsis Peptide: Review
title_short Ghrelin as an Anti-Sepsis Peptide: Review
title_sort ghrelin as an anti-sepsis peptide: review
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876230/
https://www.ncbi.nlm.nih.gov/pubmed/33584688
http://dx.doi.org/10.3389/fimmu.2020.610363
work_keys_str_mv AT mathurnimisha ghrelinasanantisepsispeptidereview
AT mehdisyedf ghrelinasanantisepsispeptidereview
AT anipindimanasa ghrelinasanantisepsispeptidereview
AT azizmonowar ghrelinasanantisepsispeptidereview
AT khansawlehaa ghrelinasanantisepsispeptidereview
AT kondakindihema ghrelinasanantisepsispeptidereview
AT lowellbarbara ghrelinasanantisepsispeptidereview
AT wangping ghrelinasanantisepsispeptidereview
AT rothjesse ghrelinasanantisepsispeptidereview