Cargando…
The Severity of Neurological Dysfunction in Preschool Children, Secondary to Damage Generated During the Perinatal Period, is Associated With a Pro-Inflammatory Pattern of Serum Molecules
Disorders in the child’s neurological development caused by perinatal risks can lead to long-term altered neurological signs that begin at an early age and involve persistent functional disorders. Recent data suggest that tissue dysfunction, not just acute damage, may initiate or perpetuate an infla...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876313/ https://www.ncbi.nlm.nih.gov/pubmed/33584663 http://dx.doi.org/10.3389/fimmu.2020.595309 |
_version_ | 1783649946649493504 |
---|---|
author | Madrid, Miriam Brianza-Padilla, Malinalli Echeverría, Juan C. Rivera-González, Rolando Bojalil, Rafael |
author_facet | Madrid, Miriam Brianza-Padilla, Malinalli Echeverría, Juan C. Rivera-González, Rolando Bojalil, Rafael |
author_sort | Madrid, Miriam |
collection | PubMed |
description | Disorders in the child’s neurological development caused by perinatal risks can lead to long-term altered neurological signs that begin at an early age and involve persistent functional disorders. Recent data suggest that tissue dysfunction, not just acute damage, may initiate or perpetuate an inflammatory response. The aim of this study was to find out if any neurological dysfunction in preschool children secondary to damage generated during the perinatal period is associated with the magnitude of perinatal risks and long-term modifications in the serum concentrations of inflammatory molecules. The participants, aged 1–4 years, were on neurodevelopmental follow-up and rehabilitation therapy from the first three months of life and had no acute disease data. We classified the children into three groups according to the importance of their perinatal risks: low, medium, and high. The results show that 1) the magnitude of perinatal risks correlated with the severity of neurological dysfunction; 2) the greatest changes in the concentrations of the molecules of the inflammatory process were associated with the most altered neurological signs. This suggests that persistent nervous system dysfunction keeps inflammatory responses active even in the absence of an acute process of infection or damage. |
format | Online Article Text |
id | pubmed-7876313 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78763132021-02-12 The Severity of Neurological Dysfunction in Preschool Children, Secondary to Damage Generated During the Perinatal Period, is Associated With a Pro-Inflammatory Pattern of Serum Molecules Madrid, Miriam Brianza-Padilla, Malinalli Echeverría, Juan C. Rivera-González, Rolando Bojalil, Rafael Front Immunol Immunology Disorders in the child’s neurological development caused by perinatal risks can lead to long-term altered neurological signs that begin at an early age and involve persistent functional disorders. Recent data suggest that tissue dysfunction, not just acute damage, may initiate or perpetuate an inflammatory response. The aim of this study was to find out if any neurological dysfunction in preschool children secondary to damage generated during the perinatal period is associated with the magnitude of perinatal risks and long-term modifications in the serum concentrations of inflammatory molecules. The participants, aged 1–4 years, were on neurodevelopmental follow-up and rehabilitation therapy from the first three months of life and had no acute disease data. We classified the children into three groups according to the importance of their perinatal risks: low, medium, and high. The results show that 1) the magnitude of perinatal risks correlated with the severity of neurological dysfunction; 2) the greatest changes in the concentrations of the molecules of the inflammatory process were associated with the most altered neurological signs. This suggests that persistent nervous system dysfunction keeps inflammatory responses active even in the absence of an acute process of infection or damage. Frontiers Media S.A. 2021-01-28 /pmc/articles/PMC7876313/ /pubmed/33584663 http://dx.doi.org/10.3389/fimmu.2020.595309 Text en Copyright © 2021 Madrid, Brianza-Padilla, Echeverría, Rivera-González and Bojalil http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Madrid, Miriam Brianza-Padilla, Malinalli Echeverría, Juan C. Rivera-González, Rolando Bojalil, Rafael The Severity of Neurological Dysfunction in Preschool Children, Secondary to Damage Generated During the Perinatal Period, is Associated With a Pro-Inflammatory Pattern of Serum Molecules |
title | The Severity of Neurological Dysfunction in Preschool Children, Secondary to Damage Generated During the Perinatal Period, is Associated With a Pro-Inflammatory Pattern of Serum Molecules |
title_full | The Severity of Neurological Dysfunction in Preschool Children, Secondary to Damage Generated During the Perinatal Period, is Associated With a Pro-Inflammatory Pattern of Serum Molecules |
title_fullStr | The Severity of Neurological Dysfunction in Preschool Children, Secondary to Damage Generated During the Perinatal Period, is Associated With a Pro-Inflammatory Pattern of Serum Molecules |
title_full_unstemmed | The Severity of Neurological Dysfunction in Preschool Children, Secondary to Damage Generated During the Perinatal Period, is Associated With a Pro-Inflammatory Pattern of Serum Molecules |
title_short | The Severity of Neurological Dysfunction in Preschool Children, Secondary to Damage Generated During the Perinatal Period, is Associated With a Pro-Inflammatory Pattern of Serum Molecules |
title_sort | severity of neurological dysfunction in preschool children, secondary to damage generated during the perinatal period, is associated with a pro-inflammatory pattern of serum molecules |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876313/ https://www.ncbi.nlm.nih.gov/pubmed/33584663 http://dx.doi.org/10.3389/fimmu.2020.595309 |
work_keys_str_mv | AT madridmiriam theseverityofneurologicaldysfunctioninpreschoolchildrensecondarytodamagegeneratedduringtheperinatalperiodisassociatedwithaproinflammatorypatternofserummolecules AT brianzapadillamalinalli theseverityofneurologicaldysfunctioninpreschoolchildrensecondarytodamagegeneratedduringtheperinatalperiodisassociatedwithaproinflammatorypatternofserummolecules AT echeverriajuanc theseverityofneurologicaldysfunctioninpreschoolchildrensecondarytodamagegeneratedduringtheperinatalperiodisassociatedwithaproinflammatorypatternofserummolecules AT riveragonzalezrolando theseverityofneurologicaldysfunctioninpreschoolchildrensecondarytodamagegeneratedduringtheperinatalperiodisassociatedwithaproinflammatorypatternofserummolecules AT bojalilrafael theseverityofneurologicaldysfunctioninpreschoolchildrensecondarytodamagegeneratedduringtheperinatalperiodisassociatedwithaproinflammatorypatternofserummolecules AT madridmiriam severityofneurologicaldysfunctioninpreschoolchildrensecondarytodamagegeneratedduringtheperinatalperiodisassociatedwithaproinflammatorypatternofserummolecules AT brianzapadillamalinalli severityofneurologicaldysfunctioninpreschoolchildrensecondarytodamagegeneratedduringtheperinatalperiodisassociatedwithaproinflammatorypatternofserummolecules AT echeverriajuanc severityofneurologicaldysfunctioninpreschoolchildrensecondarytodamagegeneratedduringtheperinatalperiodisassociatedwithaproinflammatorypatternofserummolecules AT riveragonzalezrolando severityofneurologicaldysfunctioninpreschoolchildrensecondarytodamagegeneratedduringtheperinatalperiodisassociatedwithaproinflammatorypatternofserummolecules AT bojalilrafael severityofneurologicaldysfunctioninpreschoolchildrensecondarytodamagegeneratedduringtheperinatalperiodisassociatedwithaproinflammatorypatternofserummolecules |