Green Tea Polyphenol-Sensitive Calcium Signaling in Immune T Cell Function

Polyphenol compounds found in green tea have a great therapeutic potential to influence multiple human diseases including malignancy and inflammation. In this mini review, we describe effects of green tea and the most important component EGCG in malignancy and inflammation. We focus on cellular mech...

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Detalles Bibliográficos
Autores principales: Singh, Yogesh, Salker, Madhuri S., Lang, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Nutrition
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876374/
https://www.ncbi.nlm.nih.gov/pubmed/33585537
http://dx.doi.org/10.3389/fnut.2020.616934
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author Singh, Yogesh
Salker, Madhuri S.
Lang, Florian
author_facet Singh, Yogesh
Salker, Madhuri S.
Lang, Florian
author_sort Singh, Yogesh
collection PubMed
description Polyphenol compounds found in green tea have a great therapeutic potential to influence multiple human diseases including malignancy and inflammation. In this mini review, we describe effects of green tea and the most important component EGCG in malignancy and inflammation. We focus on cellular mechanisms involved in the modification of T cell function by green tea polyphenol EGCG. The case is made that EGCG downregulates calcium channel activity by influencing miRNAs regulating expression of the channel at the post-transcriptional level.
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spelling pubmed-78763742021-02-12 Green Tea Polyphenol-Sensitive Calcium Signaling in Immune T Cell Function Singh, Yogesh Salker, Madhuri S. Lang, Florian Front Nutr Nutrition Polyphenol compounds found in green tea have a great therapeutic potential to influence multiple human diseases including malignancy and inflammation. In this mini review, we describe effects of green tea and the most important component EGCG in malignancy and inflammation. We focus on cellular mechanisms involved in the modification of T cell function by green tea polyphenol EGCG. The case is made that EGCG downregulates calcium channel activity by influencing miRNAs regulating expression of the channel at the post-transcriptional level. Frontiers Media S.A. 2021-01-28 /pmc/articles/PMC7876374/ /pubmed/33585537 http://dx.doi.org/10.3389/fnut.2020.616934 Text en Copyright © 2021 Singh, Salker and Lang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Singh, Yogesh
Salker, Madhuri S.
Lang, Florian
Green Tea Polyphenol-Sensitive Calcium Signaling in Immune T Cell Function
title Green Tea Polyphenol-Sensitive Calcium Signaling in Immune T Cell Function
title_full Green Tea Polyphenol-Sensitive Calcium Signaling in Immune T Cell Function
title_fullStr Green Tea Polyphenol-Sensitive Calcium Signaling in Immune T Cell Function
title_full_unstemmed Green Tea Polyphenol-Sensitive Calcium Signaling in Immune T Cell Function
title_short Green Tea Polyphenol-Sensitive Calcium Signaling in Immune T Cell Function
title_sort green tea polyphenol-sensitive calcium signaling in immune t cell function
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876374/
https://www.ncbi.nlm.nih.gov/pubmed/33585537
http://dx.doi.org/10.3389/fnut.2020.616934
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AT salkermadhuris greenteapolyphenolsensitivecalciumsignalinginimmunetcellfunction
AT langflorian greenteapolyphenolsensitivecalciumsignalinginimmunetcellfunction

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