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Clinical Perspectives on Liquid Biopsy in Metastatic Colorectal Cancer
Liquid biopsy, which generally refers to the analysis of biological components such as circulating nuclear acids and circulating tumor cells in body fluids, particularly in peripheral blood, has shown good capacity to overcome several limitations faced by conventional tissue biopsies. Emerging evide...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876389/ https://www.ncbi.nlm.nih.gov/pubmed/33584829 http://dx.doi.org/10.3389/fgene.2021.634642 |
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author | Gao, Wei Chen, Yigui Yang, Jianwei Zhuo, Changhua Huang, Sha Zhang, Hui Shi, Yi |
author_facet | Gao, Wei Chen, Yigui Yang, Jianwei Zhuo, Changhua Huang, Sha Zhang, Hui Shi, Yi |
author_sort | Gao, Wei |
collection | PubMed |
description | Liquid biopsy, which generally refers to the analysis of biological components such as circulating nuclear acids and circulating tumor cells in body fluids, particularly in peripheral blood, has shown good capacity to overcome several limitations faced by conventional tissue biopsies. Emerging evidence in recent decades has confirmed the promising role of liquid biopsy in the clinical management of various cancers, including colorectal cancer, which is one of the most prevalent cancers and the second leading cause of cancer-related deaths worldwide. Despite the challenges and poor clinical outcomes, patients with metastatic colorectal cancer can expect potential clinical benefits with liquid biopsy. Therefore, in this review, we focus on the clinical prospects of liquid biopsy in metastatic colorectal cancer, specifically with regard to the recently discovered various biomarkers identified on liquid biopsy. These biomarkers have been shown to be potentially useful in multiple aspects of metastatic colorectal cancer, such as auxiliary diagnosis of metastasis, prognosis prediction, and monitoring of therapy response. |
format | Online Article Text |
id | pubmed-7876389 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78763892021-02-12 Clinical Perspectives on Liquid Biopsy in Metastatic Colorectal Cancer Gao, Wei Chen, Yigui Yang, Jianwei Zhuo, Changhua Huang, Sha Zhang, Hui Shi, Yi Front Genet Genetics Liquid biopsy, which generally refers to the analysis of biological components such as circulating nuclear acids and circulating tumor cells in body fluids, particularly in peripheral blood, has shown good capacity to overcome several limitations faced by conventional tissue biopsies. Emerging evidence in recent decades has confirmed the promising role of liquid biopsy in the clinical management of various cancers, including colorectal cancer, which is one of the most prevalent cancers and the second leading cause of cancer-related deaths worldwide. Despite the challenges and poor clinical outcomes, patients with metastatic colorectal cancer can expect potential clinical benefits with liquid biopsy. Therefore, in this review, we focus on the clinical prospects of liquid biopsy in metastatic colorectal cancer, specifically with regard to the recently discovered various biomarkers identified on liquid biopsy. These biomarkers have been shown to be potentially useful in multiple aspects of metastatic colorectal cancer, such as auxiliary diagnosis of metastasis, prognosis prediction, and monitoring of therapy response. Frontiers Media S.A. 2021-01-28 /pmc/articles/PMC7876389/ /pubmed/33584829 http://dx.doi.org/10.3389/fgene.2021.634642 Text en Copyright © 2021 Gao, Chen, Yang, Zhuo, Huang, Zhang and Shi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Gao, Wei Chen, Yigui Yang, Jianwei Zhuo, Changhua Huang, Sha Zhang, Hui Shi, Yi Clinical Perspectives on Liquid Biopsy in Metastatic Colorectal Cancer |
title | Clinical Perspectives on Liquid Biopsy in Metastatic Colorectal Cancer |
title_full | Clinical Perspectives on Liquid Biopsy in Metastatic Colorectal Cancer |
title_fullStr | Clinical Perspectives on Liquid Biopsy in Metastatic Colorectal Cancer |
title_full_unstemmed | Clinical Perspectives on Liquid Biopsy in Metastatic Colorectal Cancer |
title_short | Clinical Perspectives on Liquid Biopsy in Metastatic Colorectal Cancer |
title_sort | clinical perspectives on liquid biopsy in metastatic colorectal cancer |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876389/ https://www.ncbi.nlm.nih.gov/pubmed/33584829 http://dx.doi.org/10.3389/fgene.2021.634642 |
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