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Gene Editing in Rabbits: Unique Opportunities for Translational Biomedical Research

The rabbit is a classic animal model for biomedical research, but the production of gene targeted transgenic rabbits had been extremely challenging until the recent advent of gene editing tools. More than fifty gene knockout or knock-in rabbit models have been reported in the past decade. Gene edite...

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Autores principales: Xu, Jie, Zhang, Jifeng, Yang, Dongshan, Song, Jun, Pallas, Brooke, Zhang, Chen, Hu, Jiafen, Peng, Xuwen, Christensen, Neil D., Han, Renzhi, Chen, Y. Eugene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876448/
https://www.ncbi.nlm.nih.gov/pubmed/33584832
http://dx.doi.org/10.3389/fgene.2021.642444
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author Xu, Jie
Zhang, Jifeng
Yang, Dongshan
Song, Jun
Pallas, Brooke
Zhang, Chen
Hu, Jiafen
Peng, Xuwen
Christensen, Neil D.
Han, Renzhi
Chen, Y. Eugene
author_facet Xu, Jie
Zhang, Jifeng
Yang, Dongshan
Song, Jun
Pallas, Brooke
Zhang, Chen
Hu, Jiafen
Peng, Xuwen
Christensen, Neil D.
Han, Renzhi
Chen, Y. Eugene
author_sort Xu, Jie
collection PubMed
description The rabbit is a classic animal model for biomedical research, but the production of gene targeted transgenic rabbits had been extremely challenging until the recent advent of gene editing tools. More than fifty gene knockout or knock-in rabbit models have been reported in the past decade. Gene edited (GE) rabbit models, compared to their counterpart mouse models, may offer unique opportunities in translational biomedical research attributed primarily to their relatively large size and long lifespan. More importantly, GE rabbit models have been found to mimic several disease pathologies better than their mouse counterparts particularly in fields focused on genetically inherited diseases, cardiovascular diseases, ocular diseases, and others. In this review we present selected examples of research areas where GE rabbit models are expected to make immediate contributions to the understanding of the pathophysiology of human disease, and support the development of novel therapeutics.
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spelling pubmed-78764482021-02-12 Gene Editing in Rabbits: Unique Opportunities for Translational Biomedical Research Xu, Jie Zhang, Jifeng Yang, Dongshan Song, Jun Pallas, Brooke Zhang, Chen Hu, Jiafen Peng, Xuwen Christensen, Neil D. Han, Renzhi Chen, Y. Eugene Front Genet Genetics The rabbit is a classic animal model for biomedical research, but the production of gene targeted transgenic rabbits had been extremely challenging until the recent advent of gene editing tools. More than fifty gene knockout or knock-in rabbit models have been reported in the past decade. Gene edited (GE) rabbit models, compared to their counterpart mouse models, may offer unique opportunities in translational biomedical research attributed primarily to their relatively large size and long lifespan. More importantly, GE rabbit models have been found to mimic several disease pathologies better than their mouse counterparts particularly in fields focused on genetically inherited diseases, cardiovascular diseases, ocular diseases, and others. In this review we present selected examples of research areas where GE rabbit models are expected to make immediate contributions to the understanding of the pathophysiology of human disease, and support the development of novel therapeutics. Frontiers Media S.A. 2021-01-28 /pmc/articles/PMC7876448/ /pubmed/33584832 http://dx.doi.org/10.3389/fgene.2021.642444 Text en Copyright © 2021 Xu, Zhang, Yang, Song, Pallas, Zhang, Hu, Peng, Christensen, Han and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Xu, Jie
Zhang, Jifeng
Yang, Dongshan
Song, Jun
Pallas, Brooke
Zhang, Chen
Hu, Jiafen
Peng, Xuwen
Christensen, Neil D.
Han, Renzhi
Chen, Y. Eugene
Gene Editing in Rabbits: Unique Opportunities for Translational Biomedical Research
title Gene Editing in Rabbits: Unique Opportunities for Translational Biomedical Research
title_full Gene Editing in Rabbits: Unique Opportunities for Translational Biomedical Research
title_fullStr Gene Editing in Rabbits: Unique Opportunities for Translational Biomedical Research
title_full_unstemmed Gene Editing in Rabbits: Unique Opportunities for Translational Biomedical Research
title_short Gene Editing in Rabbits: Unique Opportunities for Translational Biomedical Research
title_sort gene editing in rabbits: unique opportunities for translational biomedical research
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876448/
https://www.ncbi.nlm.nih.gov/pubmed/33584832
http://dx.doi.org/10.3389/fgene.2021.642444
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