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A T cell repertoire timestamp is at the core of responsiveness to CTLA-4 blockade

Biology of the response to anti-CTLA-4 involves the dynamics of specific T cell clones. Reasons for clinical success and failure of this treatment are still largely unknown. Here, we quantified the dynamics of the T cell receptor (TCR) repertoire, throughout 4 weeks involving treatment with anti-CTL...

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Detalles Bibliográficos
Autores principales:	Philip, Hagit, Snir, Tom, Gordin, Miri, Shugay, Mikhail, Zilberberg, Alona, Efroni, Sol
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876555/ https://www.ncbi.nlm.nih.gov/pubmed/33604527 http://dx.doi.org/10.1016/j.isci.2021.102100

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