4-(Dimethylamino)pyridine N-Oxide-Catalyzed Macrolactamization Using 2-Methyl-6-nitrobenzoic Anhydride in the Synthesis of the Depsipeptidic Analogue of FE399

[Image: see text] A depsipeptidic analogue of FE399 was efficiently synthesized mainly through macrolactamization using 2-methyl-6-nitrobenzoic anhydride (MNBA), and a detailed investigation of the desired 16-membered macrolactam core of FE399 was performed. It was determined that the combination of...

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Autores principales: Tonoi, Takayuki, Inohana, Takehiko, Kawahara, Ryo, Sato, Teruyuki, Ikeda, Miyuki, Akutsu, Miku, Murata, Takatsugu, Shiina, Isamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876680/
https://www.ncbi.nlm.nih.gov/pubmed/33585740
http://dx.doi.org/10.1021/acsomega.0c04878

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