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Are RNA-Based Tests Sufficient for COVID-19 Diagnosis? An Inspiration of Three Asymptomatic Cases

In this work, we discovered a new phenomenon—asymptomatic COVID-19 infection, or covert case, during the pandemic. All the 3 patients had a history of exposure, with no symptoms, and no abnormalities were found in computed tomography scan or lab tests. Except for case 2, the other patients’ severe a...

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Autores principales: Hu, Tao, Liu, Xiao, Yin, Qinan, Duan, Xingting, Yan, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876749/
https://www.ncbi.nlm.nih.gov/pubmed/33555211
http://dx.doi.org/10.1177/0963689720985453
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author Hu, Tao
Liu, Xiao
Yin, Qinan
Duan, Xingting
Yan, Li
author_facet Hu, Tao
Liu, Xiao
Yin, Qinan
Duan, Xingting
Yan, Li
author_sort Hu, Tao
collection PubMed
description In this work, we discovered a new phenomenon—asymptomatic COVID-19 infection, or covert case, during the pandemic. All the 3 patients had a history of exposure, with no symptoms, and no abnormalities were found in computed tomography scan or lab tests. Except for case 2, the other patients’ severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) nucleic acid tests were negative. But their anti-SARS-COV-2 nucleocapsid antibody showed a dynamic trend, consistent with the process of virus infection and clearance. A growing number of asymptomatic or covert cases need more attention. Lack of surveillance may lead to another outbreak. We hope to demonstrate our cases to attract the attention of governments or health authorities that covert cases should be the focus as well.
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spelling pubmed-78767492021-02-22 Are RNA-Based Tests Sufficient for COVID-19 Diagnosis? An Inspiration of Three Asymptomatic Cases Hu, Tao Liu, Xiao Yin, Qinan Duan, Xingting Yan, Li Cell Transplant Cell Transplantation and COVID-19 In this work, we discovered a new phenomenon—asymptomatic COVID-19 infection, or covert case, during the pandemic. All the 3 patients had a history of exposure, with no symptoms, and no abnormalities were found in computed tomography scan or lab tests. Except for case 2, the other patients’ severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) nucleic acid tests were negative. But their anti-SARS-COV-2 nucleocapsid antibody showed a dynamic trend, consistent with the process of virus infection and clearance. A growing number of asymptomatic or covert cases need more attention. Lack of surveillance may lead to another outbreak. We hope to demonstrate our cases to attract the attention of governments or health authorities that covert cases should be the focus as well. SAGE Publications 2021-02-08 /pmc/articles/PMC7876749/ /pubmed/33555211 http://dx.doi.org/10.1177/0963689720985453 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Cell Transplantation and COVID-19
Hu, Tao
Liu, Xiao
Yin, Qinan
Duan, Xingting
Yan, Li
Are RNA-Based Tests Sufficient for COVID-19 Diagnosis? An Inspiration of Three Asymptomatic Cases
title Are RNA-Based Tests Sufficient for COVID-19 Diagnosis? An Inspiration of Three Asymptomatic Cases
title_full Are RNA-Based Tests Sufficient for COVID-19 Diagnosis? An Inspiration of Three Asymptomatic Cases
title_fullStr Are RNA-Based Tests Sufficient for COVID-19 Diagnosis? An Inspiration of Three Asymptomatic Cases
title_full_unstemmed Are RNA-Based Tests Sufficient for COVID-19 Diagnosis? An Inspiration of Three Asymptomatic Cases
title_short Are RNA-Based Tests Sufficient for COVID-19 Diagnosis? An Inspiration of Three Asymptomatic Cases
title_sort are rna-based tests sufficient for covid-19 diagnosis? an inspiration of three asymptomatic cases
topic Cell Transplantation and COVID-19
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876749/
https://www.ncbi.nlm.nih.gov/pubmed/33555211
http://dx.doi.org/10.1177/0963689720985453
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