The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers

The human insulin-like growth factor 2 (IGF2) mRNA binding proteins 2 (IGF2BP2/IMP2) is an RNA-binding protein that regulates multiple biological processes. Previously, IGF2BP2 was thought to be a type 2 diabetes (T2D)-associated gene. Indeed IGF2BP2 modulates cellular metabolism in human metabolic...

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Autores principales: Wang, Jinyan, Chen, Lijuan, Qiang, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876817/
https://www.ncbi.nlm.nih.gov/pubmed/33568150
http://dx.doi.org/10.1186/s12935-021-01799-x
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author Wang, Jinyan
Chen, Lijuan
Qiang, Ping
author_facet Wang, Jinyan
Chen, Lijuan
Qiang, Ping
author_sort Wang, Jinyan
collection PubMed
description The human insulin-like growth factor 2 (IGF2) mRNA binding proteins 2 (IGF2BP2/IMP2) is an RNA-binding protein that regulates multiple biological processes. Previously, IGF2BP2 was thought to be a type 2 diabetes (T2D)-associated gene. Indeed IGF2BP2 modulates cellular metabolism in human metabolic diseases such as diabetes, obesity and fatty liver through post-transcriptional regulation of numerous genes in multiple cell types. Emerging evidence shows that IGF2BP2 is an N6-methyladenosine (m6A) reader that participates in the development and progression of cancers by communicating with different RNAs such as microRNAs (miRNAs), messenger RNAs (mRNAs) and long non-coding RNAs (lncRNAs). Additionally, IGF2BP2 is an independent prognostic factor for multiple cancer types. In this review, we summarize the current knowledge on IGF2BP2 with regard to diverse human metabolic diseases and its potential for cancer prognosis.
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spelling pubmed-78768172021-02-11 The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers Wang, Jinyan Chen, Lijuan Qiang, Ping Cancer Cell Int Review The human insulin-like growth factor 2 (IGF2) mRNA binding proteins 2 (IGF2BP2/IMP2) is an RNA-binding protein that regulates multiple biological processes. Previously, IGF2BP2 was thought to be a type 2 diabetes (T2D)-associated gene. Indeed IGF2BP2 modulates cellular metabolism in human metabolic diseases such as diabetes, obesity and fatty liver through post-transcriptional regulation of numerous genes in multiple cell types. Emerging evidence shows that IGF2BP2 is an N6-methyladenosine (m6A) reader that participates in the development and progression of cancers by communicating with different RNAs such as microRNAs (miRNAs), messenger RNAs (mRNAs) and long non-coding RNAs (lncRNAs). Additionally, IGF2BP2 is an independent prognostic factor for multiple cancer types. In this review, we summarize the current knowledge on IGF2BP2 with regard to diverse human metabolic diseases and its potential for cancer prognosis. BioMed Central 2021-02-10 /pmc/articles/PMC7876817/ /pubmed/33568150 http://dx.doi.org/10.1186/s12935-021-01799-x Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Wang, Jinyan
Chen, Lijuan
Qiang, Ping
The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers
title The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers
title_full The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers
title_fullStr The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers
title_full_unstemmed The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers
title_short The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers
title_sort role of igf2bp2, an m6a reader gene, in human metabolic diseases and cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876817/
https://www.ncbi.nlm.nih.gov/pubmed/33568150
http://dx.doi.org/10.1186/s12935-021-01799-x
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