Cargando…
Liposomal Dendritic Cell Vaccine in Breast Cancer Immunotherapy
[Image: see text] Cancer vaccine is well recognized as a promising approach for immunotherapy of cancers. Since dendritic cells (DCs) are capable of processing and presenting antigens to initiate the immune response cascade, the development of DC vaccines is considered as a good choice for the treat...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876850/ https://www.ncbi.nlm.nih.gov/pubmed/33585776 http://dx.doi.org/10.1021/acsomega.0c05924 |
_version_ | 1783650051324641280 |
---|---|
author | Pan, Hong Shi, Hongyan Fu, Peng Shi, Pengfei Yang, Jianyuan |
author_facet | Pan, Hong Shi, Hongyan Fu, Peng Shi, Pengfei Yang, Jianyuan |
author_sort | Pan, Hong |
collection | PubMed |
description | [Image: see text] Cancer vaccine is well recognized as a promising approach for immunotherapy of cancers. Since dendritic cells (DCs) are capable of processing and presenting antigens to initiate the immune response cascade, the development of DC vaccines is considered as a good choice for the treatment of cancer. Herein, a folic acid (FA)-modified liposome was constructed and loaded with chlorin e6 (Ce6) as a DC vaccine (FA-Lipo-Ce6). It was suggested that the loaded Ce6 within FA-Lipo-Ce6 can be activated under laser irradiation. The photodynamic therapy (PDT) of Ce6 was expected to create on-demand reactive oxygen species (ROS) in situ, which causes cell death and trigger the exposure of tumor-associated antigen (TAA). In addition, the produced ROS can mimic the inflammatory responses for the employment of DC for better antigen presentation and immune response. Most importantly, the employment of DC can recognize the exposed TAA to stimulate DC for effective vaccination in situ. Our results demonstrated the powerful capacity of FA-Lipo-Ce6 to induce DC activation, leading to effective suppression of the growth of breast cancers. |
format | Online Article Text |
id | pubmed-7876850 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-78768502021-02-12 Liposomal Dendritic Cell Vaccine in Breast Cancer Immunotherapy Pan, Hong Shi, Hongyan Fu, Peng Shi, Pengfei Yang, Jianyuan ACS Omega [Image: see text] Cancer vaccine is well recognized as a promising approach for immunotherapy of cancers. Since dendritic cells (DCs) are capable of processing and presenting antigens to initiate the immune response cascade, the development of DC vaccines is considered as a good choice for the treatment of cancer. Herein, a folic acid (FA)-modified liposome was constructed and loaded with chlorin e6 (Ce6) as a DC vaccine (FA-Lipo-Ce6). It was suggested that the loaded Ce6 within FA-Lipo-Ce6 can be activated under laser irradiation. The photodynamic therapy (PDT) of Ce6 was expected to create on-demand reactive oxygen species (ROS) in situ, which causes cell death and trigger the exposure of tumor-associated antigen (TAA). In addition, the produced ROS can mimic the inflammatory responses for the employment of DC for better antigen presentation and immune response. Most importantly, the employment of DC can recognize the exposed TAA to stimulate DC for effective vaccination in situ. Our results demonstrated the powerful capacity of FA-Lipo-Ce6 to induce DC activation, leading to effective suppression of the growth of breast cancers. American Chemical Society 2021-01-25 /pmc/articles/PMC7876850/ /pubmed/33585776 http://dx.doi.org/10.1021/acsomega.0c05924 Text en © 2021 The Authors. Published by American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes. |
spellingShingle | Pan, Hong Shi, Hongyan Fu, Peng Shi, Pengfei Yang, Jianyuan Liposomal Dendritic Cell Vaccine in Breast Cancer Immunotherapy |
title | Liposomal Dendritic Cell Vaccine in Breast Cancer
Immunotherapy |
title_full | Liposomal Dendritic Cell Vaccine in Breast Cancer
Immunotherapy |
title_fullStr | Liposomal Dendritic Cell Vaccine in Breast Cancer
Immunotherapy |
title_full_unstemmed | Liposomal Dendritic Cell Vaccine in Breast Cancer
Immunotherapy |
title_short | Liposomal Dendritic Cell Vaccine in Breast Cancer
Immunotherapy |
title_sort | liposomal dendritic cell vaccine in breast cancer
immunotherapy |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876850/ https://www.ncbi.nlm.nih.gov/pubmed/33585776 http://dx.doi.org/10.1021/acsomega.0c05924 |
work_keys_str_mv | AT panhong liposomaldendriticcellvaccineinbreastcancerimmunotherapy AT shihongyan liposomaldendriticcellvaccineinbreastcancerimmunotherapy AT fupeng liposomaldendriticcellvaccineinbreastcancerimmunotherapy AT shipengfei liposomaldendriticcellvaccineinbreastcancerimmunotherapy AT yangjianyuan liposomaldendriticcellvaccineinbreastcancerimmunotherapy |