Enhancing Tumor Accumulation and Cellular Uptake of Layered Double Hydroxide Nanoparticles by Coating/Detaching pH-Triggered Charge-Convertible Polymers
[Image: see text] Layered double hydroxide (LDH) nanoparticles are extensively explored as multifunctional nanocarriers due to their versatility in both the host layer and the interlayer anion. In this study, we report modification of positively charged Cu-containing LDH nanoparticles with a pH-resp...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876861/ https://www.ncbi.nlm.nih.gov/pubmed/33585761 http://dx.doi.org/10.1021/acsomega.0c05520 |
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author | Xu, Tiefeng Liu, Jianping Sun, Luyao Zhang, Run Xu, Zhi Ping Sun, Qing |
author_facet | Xu, Tiefeng Liu, Jianping Sun, Luyao Zhang, Run Xu, Zhi Ping Sun, Qing |
author_sort | Xu, Tiefeng |
collection | PubMed |
description | [Image: see text] Layered double hydroxide (LDH) nanoparticles are extensively explored as multifunctional nanocarriers due to their versatility in both the host layer and the interlayer anion. In this study, we report modification of positively charged Cu-containing LDH nanoparticles with a pH-responsive charge-changeable polymer to improve the particle colloidal stability in blood circulation, reduce the nonspecific uptake by normal cells in organs, and subsequently facilitate tumor accumulation and uptake by tumor cells in the acidic tumor microenvironment. In vitro experimental results demonstrate that this promising charge-convertible polymer–LDH nanocarrier well reduces the capture by macrophages in the physiologic medium (pH 7.4) but facilitates the uptake by tumor cells due to detaching of the coated polymer layer in the weakly acidic condition (pH 6.8). Cu-containing LDH nanoparticles also show pH-responsive magnetic resonance imaging (MRI) contrast capacity (i.e., r(1) relaxivity). In vivo MRI further confirms effective tumor accumulation of the charge-convertible nanohybrids, with ∼4.8% of the injected dose accumulated at 24 h postintravenous injection, proving the potential as a versatile delivery nanocarrier to enhance the antitumor treatment. |
format | Online Article Text |
id | pubmed-7876861 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-78768612021-02-12 Enhancing Tumor Accumulation and Cellular Uptake of Layered Double Hydroxide Nanoparticles by Coating/Detaching pH-Triggered Charge-Convertible Polymers Xu, Tiefeng Liu, Jianping Sun, Luyao Zhang, Run Xu, Zhi Ping Sun, Qing ACS Omega [Image: see text] Layered double hydroxide (LDH) nanoparticles are extensively explored as multifunctional nanocarriers due to their versatility in both the host layer and the interlayer anion. In this study, we report modification of positively charged Cu-containing LDH nanoparticles with a pH-responsive charge-changeable polymer to improve the particle colloidal stability in blood circulation, reduce the nonspecific uptake by normal cells in organs, and subsequently facilitate tumor accumulation and uptake by tumor cells in the acidic tumor microenvironment. In vitro experimental results demonstrate that this promising charge-convertible polymer–LDH nanocarrier well reduces the capture by macrophages in the physiologic medium (pH 7.4) but facilitates the uptake by tumor cells due to detaching of the coated polymer layer in the weakly acidic condition (pH 6.8). Cu-containing LDH nanoparticles also show pH-responsive magnetic resonance imaging (MRI) contrast capacity (i.e., r(1) relaxivity). In vivo MRI further confirms effective tumor accumulation of the charge-convertible nanohybrids, with ∼4.8% of the injected dose accumulated at 24 h postintravenous injection, proving the potential as a versatile delivery nanocarrier to enhance the antitumor treatment. American Chemical Society 2021-01-27 /pmc/articles/PMC7876861/ /pubmed/33585761 http://dx.doi.org/10.1021/acsomega.0c05520 Text en © 2021 The Authors. Published by American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes. |
spellingShingle | Xu, Tiefeng Liu, Jianping Sun, Luyao Zhang, Run Xu, Zhi Ping Sun, Qing Enhancing Tumor Accumulation and Cellular Uptake of Layered Double Hydroxide Nanoparticles by Coating/Detaching pH-Triggered Charge-Convertible Polymers |
title | Enhancing Tumor Accumulation and Cellular Uptake of
Layered Double Hydroxide Nanoparticles by Coating/Detaching pH-Triggered
Charge-Convertible Polymers |
title_full | Enhancing Tumor Accumulation and Cellular Uptake of
Layered Double Hydroxide Nanoparticles by Coating/Detaching pH-Triggered
Charge-Convertible Polymers |
title_fullStr | Enhancing Tumor Accumulation and Cellular Uptake of
Layered Double Hydroxide Nanoparticles by Coating/Detaching pH-Triggered
Charge-Convertible Polymers |
title_full_unstemmed | Enhancing Tumor Accumulation and Cellular Uptake of
Layered Double Hydroxide Nanoparticles by Coating/Detaching pH-Triggered
Charge-Convertible Polymers |
title_short | Enhancing Tumor Accumulation and Cellular Uptake of
Layered Double Hydroxide Nanoparticles by Coating/Detaching pH-Triggered
Charge-Convertible Polymers |
title_sort | enhancing tumor accumulation and cellular uptake of
layered double hydroxide nanoparticles by coating/detaching ph-triggered
charge-convertible polymers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876861/ https://www.ncbi.nlm.nih.gov/pubmed/33585761 http://dx.doi.org/10.1021/acsomega.0c05520 |
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