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Tumoral Volume Measured Preoperatively by Magnetic Resonance Imaging is Related to Survival in Endometrial Cancer
BACKGROUND: The aim of the study was to determine if the endometrial tumor volume (TV) measured by magnetic resonance imaging (MRI-TV) is associated with survival in endometrial cancer and lymph nodes metastases (LN+). PATIENTS AND METHODS: We evaluated the MRI imaging and records of 341 women with...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sciendo
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877259/ https://www.ncbi.nlm.nih.gov/pubmed/33885237 http://dx.doi.org/10.2478/raon-2020-0064 |
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author | Coronado, Pluvio J. de Santiago-López, Javier de Santiago-García, Javier Méndez, Ramiro Fasero, Maria Herraiz, Miguel A. |
author_facet | Coronado, Pluvio J. de Santiago-López, Javier de Santiago-García, Javier Méndez, Ramiro Fasero, Maria Herraiz, Miguel A. |
author_sort | Coronado, Pluvio J. |
collection | PubMed |
description | BACKGROUND: The aim of the study was to determine if the endometrial tumor volume (TV) measured by magnetic resonance imaging (MRI-TV) is associated with survival in endometrial cancer and lymph nodes metastases (LN+). PATIENTS AND METHODS: We evaluated the MRI imaging and records of 341 women with endometrial cancer and preoperative MRI from 2008 to 2018. The MRI-TV was calculated using the ellipsoid formula measuring three perpendicular tumor diameters. Tumor myometrial invasion was also analyzed. RESULTS: Higher MRI-TV was associated with age ≥ 65y, non-endometrioid tumors, grade-3, deep-myometrial invasion, LN+ and advanced FIGO stage. There were 37 patients with LN+ (8.8%). Non-endometrioid tumors, deep-myometrial invasion, grade-3 and MRI-TV ≥ 10 cm(3) were the factors associated with LN+. Using a receiver operating characteristic [ROC] curve, the MRI-TV cut-off for survival was 10 cm(3) (area under curve [AUC] = 0.70; 95% CI: 0.61–0.73). 5 years disease-free (DFS) and overall survival (OS) was significantly lower in MRI-TV ≥ 10 cm(3) (69.3% vs. 84.5%, and 75.4% vs. 96.1%, respectively). MRI-TV was considered an independent factor of DFS (HR: 2.20, 95% CI: 1.09–4.45, p = 0.029) and OS (HR: 3.88, 95% CI: 1.34–11.24, p = 0.012) in multivariate analysis. CONCLUSIONS: MRI-TV was associated with LN+, and MRI-TV ≥ 10 cm(3) was an independent prognostic factor of lower DFS and OS. The MRI-TV can be auxiliary information to plan the surgery strategy and predict the adjuvant treatment in women with endometrial cancer. |
format | Online Article Text |
id | pubmed-7877259 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Sciendo |
record_format | MEDLINE/PubMed |
spelling | pubmed-78772592021-03-01 Tumoral Volume Measured Preoperatively by Magnetic Resonance Imaging is Related to Survival in Endometrial Cancer Coronado, Pluvio J. de Santiago-López, Javier de Santiago-García, Javier Méndez, Ramiro Fasero, Maria Herraiz, Miguel A. Radiol Oncol Research Article BACKGROUND: The aim of the study was to determine if the endometrial tumor volume (TV) measured by magnetic resonance imaging (MRI-TV) is associated with survival in endometrial cancer and lymph nodes metastases (LN+). PATIENTS AND METHODS: We evaluated the MRI imaging and records of 341 women with endometrial cancer and preoperative MRI from 2008 to 2018. The MRI-TV was calculated using the ellipsoid formula measuring three perpendicular tumor diameters. Tumor myometrial invasion was also analyzed. RESULTS: Higher MRI-TV was associated with age ≥ 65y, non-endometrioid tumors, grade-3, deep-myometrial invasion, LN+ and advanced FIGO stage. There were 37 patients with LN+ (8.8%). Non-endometrioid tumors, deep-myometrial invasion, grade-3 and MRI-TV ≥ 10 cm(3) were the factors associated with LN+. Using a receiver operating characteristic [ROC] curve, the MRI-TV cut-off for survival was 10 cm(3) (area under curve [AUC] = 0.70; 95% CI: 0.61–0.73). 5 years disease-free (DFS) and overall survival (OS) was significantly lower in MRI-TV ≥ 10 cm(3) (69.3% vs. 84.5%, and 75.4% vs. 96.1%, respectively). MRI-TV was considered an independent factor of DFS (HR: 2.20, 95% CI: 1.09–4.45, p = 0.029) and OS (HR: 3.88, 95% CI: 1.34–11.24, p = 0.012) in multivariate analysis. CONCLUSIONS: MRI-TV was associated with LN+, and MRI-TV ≥ 10 cm(3) was an independent prognostic factor of lower DFS and OS. The MRI-TV can be auxiliary information to plan the surgery strategy and predict the adjuvant treatment in women with endometrial cancer. Sciendo 2021-01-12 /pmc/articles/PMC7877259/ /pubmed/33885237 http://dx.doi.org/10.2478/raon-2020-0064 Text en © 2021 Pluvio J. Coronado, Javier de Santiago-López, Javier de Santiago-García, Ramiro Méndez, Maria Fasero, Miguel A. Herraiz, published by Sciendo http://creativecommons.org/licenses/by-nc-nd/3.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. |
spellingShingle | Research Article Coronado, Pluvio J. de Santiago-López, Javier de Santiago-García, Javier Méndez, Ramiro Fasero, Maria Herraiz, Miguel A. Tumoral Volume Measured Preoperatively by Magnetic Resonance Imaging is Related to Survival in Endometrial Cancer |
title | Tumoral Volume Measured Preoperatively by Magnetic Resonance Imaging is Related to Survival in Endometrial Cancer |
title_full | Tumoral Volume Measured Preoperatively by Magnetic Resonance Imaging is Related to Survival in Endometrial Cancer |
title_fullStr | Tumoral Volume Measured Preoperatively by Magnetic Resonance Imaging is Related to Survival in Endometrial Cancer |
title_full_unstemmed | Tumoral Volume Measured Preoperatively by Magnetic Resonance Imaging is Related to Survival in Endometrial Cancer |
title_short | Tumoral Volume Measured Preoperatively by Magnetic Resonance Imaging is Related to Survival in Endometrial Cancer |
title_sort | tumoral volume measured preoperatively by magnetic resonance imaging is related to survival in endometrial cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877259/ https://www.ncbi.nlm.nih.gov/pubmed/33885237 http://dx.doi.org/10.2478/raon-2020-0064 |
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