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Physical Activity and Cancer Risk. Actual Knowledge and Possible Biological Mechanisms

BACKGROUND: Scientific evidence has shown that an increase in regular physical activity is associated with a decrease in the development of many types of cancer. Potential mechanisms that link physical activity to reduced cancer risk include a decrease in systemic inflammation, hyperinsulinemia, ins...

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Autor principal: Jurdana, Mihaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sciendo 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877262/
https://www.ncbi.nlm.nih.gov/pubmed/33885236
http://dx.doi.org/10.2478/raon-2020-0063
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author Jurdana, Mihaela
author_facet Jurdana, Mihaela
author_sort Jurdana, Mihaela
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description BACKGROUND: Scientific evidence has shown that an increase in regular physical activity is associated with a decrease in the development of many types of cancer. Potential mechanisms that link physical activity to reduced cancer risk include a decrease in systemic inflammation, hyperinsulinemia, insulin-like growth factor (IGF-I), sex hormones, pro-inflammatory leptin and other obesity-related cytokines, and a significant increase in anti-inflammatory adiponectin levels. In addition, physical activity improves immune function and the composition and diversity of the gastrointestinal microbiota. Moderate physical activity is important for cancer protection, but the most significant changes in the inflammatory profile are conferred by physical activity performed at higher intensities. Thus, there is a need for further investigation into the type, intensity, and duration of physical activity for the prevention of some types of cancer and the development of effective recommendations. CONCLUSIONS: There is a strong evidence that physical activity of moderate to vigorous intensity protects against colon and breast cancer, and probably against cancer at all other sites.
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spelling pubmed-78772622021-03-01 Physical Activity and Cancer Risk. Actual Knowledge and Possible Biological Mechanisms Jurdana, Mihaela Radiol Oncol Review BACKGROUND: Scientific evidence has shown that an increase in regular physical activity is associated with a decrease in the development of many types of cancer. Potential mechanisms that link physical activity to reduced cancer risk include a decrease in systemic inflammation, hyperinsulinemia, insulin-like growth factor (IGF-I), sex hormones, pro-inflammatory leptin and other obesity-related cytokines, and a significant increase in anti-inflammatory adiponectin levels. In addition, physical activity improves immune function and the composition and diversity of the gastrointestinal microbiota. Moderate physical activity is important for cancer protection, but the most significant changes in the inflammatory profile are conferred by physical activity performed at higher intensities. Thus, there is a need for further investigation into the type, intensity, and duration of physical activity for the prevention of some types of cancer and the development of effective recommendations. CONCLUSIONS: There is a strong evidence that physical activity of moderate to vigorous intensity protects against colon and breast cancer, and probably against cancer at all other sites. Sciendo 2021-01-12 /pmc/articles/PMC7877262/ /pubmed/33885236 http://dx.doi.org/10.2478/raon-2020-0063 Text en © 2021 Mihaela Jurdana, published by Sciendo http://creativecommons.org/licenses/by-nc-nd/3.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
spellingShingle Review
Jurdana, Mihaela
Physical Activity and Cancer Risk. Actual Knowledge and Possible Biological Mechanisms
title Physical Activity and Cancer Risk. Actual Knowledge and Possible Biological Mechanisms
title_full Physical Activity and Cancer Risk. Actual Knowledge and Possible Biological Mechanisms
title_fullStr Physical Activity and Cancer Risk. Actual Knowledge and Possible Biological Mechanisms
title_full_unstemmed Physical Activity and Cancer Risk. Actual Knowledge and Possible Biological Mechanisms
title_short Physical Activity and Cancer Risk. Actual Knowledge and Possible Biological Mechanisms
title_sort physical activity and cancer risk. actual knowledge and possible biological mechanisms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877262/
https://www.ncbi.nlm.nih.gov/pubmed/33885236
http://dx.doi.org/10.2478/raon-2020-0063
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