A new cytokine‐based dynamic stratification during induction is highly predictive of survivals in acute myeloid leukemia

The aim of this study was to assess the potential impact of the kinetics of serum levels of seven cytokines during induction in acute myeloid leukemia (AML) patients. Indeed, the role of cytokines, in the pathophysiology and response to therapy of AML patients, remains under investigation. Here, we...

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Autores principales: Peterlin, Pierre, Gaschet, Joelle, Guillaume, Thierry, Garnier, Alice, Eveillard, Marion, Le Bourgeois, Amandine, Cherel, Michel, Debord, Camille, Le Bris, Yannick, Theisen, Olivier, Godon, Catherine, Mahé, Béatrice, Dubruille, Viviane, Wuilleme, Soraya, Touzeau, Cyrille, Gastinne, Thomas, Blin, Nicolas, Lok, Anne, Tessoulin, Benoît, Le Gouill, Steven, Moreau, Philippe, Béné, Marie‐C, Chevallier, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Clinical Cancer Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877358/
https://www.ncbi.nlm.nih.gov/pubmed/33369136
http://dx.doi.org/10.1002/cam4.3648
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author Peterlin, Pierre
Gaschet, Joelle
Guillaume, Thierry
Garnier, Alice
Eveillard, Marion
Le Bourgeois, Amandine
Cherel, Michel
Debord, Camille
Le Bris, Yannick
Theisen, Olivier
Godon, Catherine
Mahé, Béatrice
Dubruille, Viviane
Wuilleme, Soraya
Touzeau, Cyrille
Gastinne, Thomas
Blin, Nicolas
Lok, Anne
Tessoulin, Benoît
Le Gouill, Steven
Moreau, Philippe
Béné, Marie‐C
Chevallier, Patrice
author_facet Peterlin, Pierre
Gaschet, Joelle
Guillaume, Thierry
Garnier, Alice
Eveillard, Marion
Le Bourgeois, Amandine
Cherel, Michel
Debord, Camille
Le Bris, Yannick
Theisen, Olivier
Godon, Catherine
Mahé, Béatrice
Dubruille, Viviane
Wuilleme, Soraya
Touzeau, Cyrille
Gastinne, Thomas
Blin, Nicolas
Lok, Anne
Tessoulin, Benoît
Le Gouill, Steven
Moreau, Philippe
Béné, Marie‐C
Chevallier, Patrice
author_sort Peterlin, Pierre
collection PubMed
description The aim of this study was to assess the potential impact of the kinetics of serum levels of seven cytokines during induction in acute myeloid leukemia (AML) patients. Indeed, the role of cytokines, in the pathophysiology and response to therapy of AML patients, remains under investigation. Here, we report on the impact of peripheral levels of two cytokines, the Fms‐like tyrosine kinase 3 ligand (FL) and interleukin‐6 (IL‐6), evaluated during first‐line intensive induction. A new risk stratification can be proposed, which supersedes the ELN 2017 classification to predict survivals in AML patients by examining the kinetic profile of these cytokines during the induction phase. It segregates three groups of, respectively, high‐risk, characterized by a stagnation of low FL levels, intermediate risk, with dynamic increasing FL levels and high IL‐6 at day 22, and favorable risk with increasing FL levels but low IL‐6 at day 22.
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spelling pubmed-78773582021-02-18 A new cytokine‐based dynamic stratification during induction is highly predictive of survivals in acute myeloid leukemia Peterlin, Pierre Gaschet, Joelle Guillaume, Thierry Garnier, Alice Eveillard, Marion Le Bourgeois, Amandine Cherel, Michel Debord, Camille Le Bris, Yannick Theisen, Olivier Godon, Catherine Mahé, Béatrice Dubruille, Viviane Wuilleme, Soraya Touzeau, Cyrille Gastinne, Thomas Blin, Nicolas Lok, Anne Tessoulin, Benoît Le Gouill, Steven Moreau, Philippe Béné, Marie‐C Chevallier, Patrice Cancer Med Clinical Cancer Research The aim of this study was to assess the potential impact of the kinetics of serum levels of seven cytokines during induction in acute myeloid leukemia (AML) patients. Indeed, the role of cytokines, in the pathophysiology and response to therapy of AML patients, remains under investigation. Here, we report on the impact of peripheral levels of two cytokines, the Fms‐like tyrosine kinase 3 ligand (FL) and interleukin‐6 (IL‐6), evaluated during first‐line intensive induction. A new risk stratification can be proposed, which supersedes the ELN 2017 classification to predict survivals in AML patients by examining the kinetic profile of these cytokines during the induction phase. It segregates three groups of, respectively, high‐risk, characterized by a stagnation of low FL levels, intermediate risk, with dynamic increasing FL levels and high IL‐6 at day 22, and favorable risk with increasing FL levels but low IL‐6 at day 22. John Wiley and Sons Inc. 2020-12-25 /pmc/articles/PMC7877358/ /pubmed/33369136 http://dx.doi.org/10.1002/cam4.3648 Text en © 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Cancer Research
Peterlin, Pierre
Gaschet, Joelle
Guillaume, Thierry
Garnier, Alice
Eveillard, Marion
Le Bourgeois, Amandine
Cherel, Michel
Debord, Camille
Le Bris, Yannick
Theisen, Olivier
Godon, Catherine
Mahé, Béatrice
Dubruille, Viviane
Wuilleme, Soraya
Touzeau, Cyrille
Gastinne, Thomas
Blin, Nicolas
Lok, Anne
Tessoulin, Benoît
Le Gouill, Steven
Moreau, Philippe
Béné, Marie‐C
Chevallier, Patrice
A new cytokine‐based dynamic stratification during induction is highly predictive of survivals in acute myeloid leukemia
title A new cytokine‐based dynamic stratification during induction is highly predictive of survivals in acute myeloid leukemia
title_full A new cytokine‐based dynamic stratification during induction is highly predictive of survivals in acute myeloid leukemia
title_fullStr A new cytokine‐based dynamic stratification during induction is highly predictive of survivals in acute myeloid leukemia
title_full_unstemmed A new cytokine‐based dynamic stratification during induction is highly predictive of survivals in acute myeloid leukemia
title_short A new cytokine‐based dynamic stratification during induction is highly predictive of survivals in acute myeloid leukemia
title_sort new cytokine‐based dynamic stratification during induction is highly predictive of survivals in acute myeloid leukemia
topic Clinical Cancer Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877358/
https://www.ncbi.nlm.nih.gov/pubmed/33369136
http://dx.doi.org/10.1002/cam4.3648
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