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Sodium Fluorescein for Spinal Intradural Tumors

Technological innovations in spinal intradural tumor surgery simplify treatment. Surgical treatment of cranial benign and malignant pathologies under microscope with sodium (Na)-fluorescein guidance has often been reported, but few studies have focused on spinal intradural tumors. We aimed to invest...

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Autores principales: Olguner, Semih Kivanc, Arslan, Ali, Açık, Vedat, İstemen, İsmail, Can, Mehmet, Gezercan, Yurdal, Ökten, Ali İhsan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877540/
https://www.ncbi.nlm.nih.gov/pubmed/33585245
http://dx.doi.org/10.3389/fonc.2020.618579
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author Olguner, Semih Kivanc
Arslan, Ali
Açık, Vedat
İstemen, İsmail
Can, Mehmet
Gezercan, Yurdal
Ökten, Ali İhsan
author_facet Olguner, Semih Kivanc
Arslan, Ali
Açık, Vedat
İstemen, İsmail
Can, Mehmet
Gezercan, Yurdal
Ökten, Ali İhsan
author_sort Olguner, Semih Kivanc
collection PubMed
description Technological innovations in spinal intradural tumor surgery simplify treatment. Surgical treatment of cranial benign and malignant pathologies under microscope with sodium (Na)-fluorescein guidance has often been reported, but few studies have focused on spinal intradural tumors. We aimed to investigate the usefulness of Na-fluorescein under yellow filter in intradural spinal tumor surgery by retrospectively reviewing cases involving intramedullary and extramedullary tumors operated under the guidance of Na-fluorescein. Forty-nine adult patients with a diagnosis of spinal intradural tumor operated under a yellow filter (560 nm) microscope using Na-fluorescein dye were included in the study. Demographic data, such as age and sex, neurological status, extent of tumor resection, histopathological diagnosis, Na-fluorescein staining pattern, and its usefulness during surgery were noted and statistically analyzed. Of all recruited patients, 26 women (53.1%) and 23 men (46.9%), were included for analysis. The age range of the patients was 18–64 years, with a mean age of 41.6 ± 13.9. An intradural intramedullary mass was found in 30.6% (n = 15) of the patients, and an intradural extramedullary mass in 69.4% (n: 34). While Na-fluorescein staining was homogeneous in all intradural extramedullary tumors, 73.3% (n: 11) of intradural intramedullary tumors were homogeneous, and 13.3% (n: 2) moderately heterogeneous. In the whole study group, the Na-fluorescein staining pattern was helpful in surgical resection in 47 cases (95.9%). While 34/34 (100%) found it helpful for extramedullary tumors, 13/15 (86.7%) did in intramedullary tumors, and for 2/15 (13.3%) it was not. In conclusion, Na-fluorescein helps in distinguishing tumor from healthy tissue in intradural extramedullary and intramedullary tumor surgery under a yellow filter microscope in most cases, thus providing convenient assistance to surgeons.
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spelling pubmed-78775402021-02-12 Sodium Fluorescein for Spinal Intradural Tumors Olguner, Semih Kivanc Arslan, Ali Açık, Vedat İstemen, İsmail Can, Mehmet Gezercan, Yurdal Ökten, Ali İhsan Front Oncol Oncology Technological innovations in spinal intradural tumor surgery simplify treatment. Surgical treatment of cranial benign and malignant pathologies under microscope with sodium (Na)-fluorescein guidance has often been reported, but few studies have focused on spinal intradural tumors. We aimed to investigate the usefulness of Na-fluorescein under yellow filter in intradural spinal tumor surgery by retrospectively reviewing cases involving intramedullary and extramedullary tumors operated under the guidance of Na-fluorescein. Forty-nine adult patients with a diagnosis of spinal intradural tumor operated under a yellow filter (560 nm) microscope using Na-fluorescein dye were included in the study. Demographic data, such as age and sex, neurological status, extent of tumor resection, histopathological diagnosis, Na-fluorescein staining pattern, and its usefulness during surgery were noted and statistically analyzed. Of all recruited patients, 26 women (53.1%) and 23 men (46.9%), were included for analysis. The age range of the patients was 18–64 years, with a mean age of 41.6 ± 13.9. An intradural intramedullary mass was found in 30.6% (n = 15) of the patients, and an intradural extramedullary mass in 69.4% (n: 34). While Na-fluorescein staining was homogeneous in all intradural extramedullary tumors, 73.3% (n: 11) of intradural intramedullary tumors were homogeneous, and 13.3% (n: 2) moderately heterogeneous. In the whole study group, the Na-fluorescein staining pattern was helpful in surgical resection in 47 cases (95.9%). While 34/34 (100%) found it helpful for extramedullary tumors, 13/15 (86.7%) did in intramedullary tumors, and for 2/15 (13.3%) it was not. In conclusion, Na-fluorescein helps in distinguishing tumor from healthy tissue in intradural extramedullary and intramedullary tumor surgery under a yellow filter microscope in most cases, thus providing convenient assistance to surgeons. Frontiers Media S.A. 2021-01-28 /pmc/articles/PMC7877540/ /pubmed/33585245 http://dx.doi.org/10.3389/fonc.2020.618579 Text en Copyright © 2021 Olguner, Arslan, Açık, İstemen, Can, Gezercan and Ökten http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Olguner, Semih Kivanc
Arslan, Ali
Açık, Vedat
İstemen, İsmail
Can, Mehmet
Gezercan, Yurdal
Ökten, Ali İhsan
Sodium Fluorescein for Spinal Intradural Tumors
title Sodium Fluorescein for Spinal Intradural Tumors
title_full Sodium Fluorescein for Spinal Intradural Tumors
title_fullStr Sodium Fluorescein for Spinal Intradural Tumors
title_full_unstemmed Sodium Fluorescein for Spinal Intradural Tumors
title_short Sodium Fluorescein for Spinal Intradural Tumors
title_sort sodium fluorescein for spinal intradural tumors
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877540/
https://www.ncbi.nlm.nih.gov/pubmed/33585245
http://dx.doi.org/10.3389/fonc.2020.618579
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