Cargando…
In silico analysis suggests less effective MHC-II presentation of SARS-CoV-2 RBM peptides: Implication for neutralizing antibody responses
SARS-CoV-2 antibodies develop within two weeks of infection, but wane relatively rapidly post-infection, raising concerns about whether antibody responses will provide protection upon re-exposure. Here we revisit T-B cooperation as a prerequisite for effective and durable neutralizing antibody respo...
Autores principales: | Castro, Andrea, Ozturk, Kivilcim, Zanetti, Maurizio, Carter, Hannah |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877779/ https://www.ncbi.nlm.nih.gov/pubmed/33571241 http://dx.doi.org/10.1371/journal.pone.0246731 |
Ejemplares similares
-
MHC-II constrains the natural neutralizing antibody response to the SARS-CoV-2 spike RBM in humans
por: Castro, Andrea, et al.
Publicado: (2020) -
Elevated neoantigen levels in tumors with somatic mutations in the HLA-A, HLA-B, HLA-C and B2M genes
por: Castro, Andrea, et al.
Publicado: (2019) -
Structure-selected RBM immunogens prime polyclonal memory responses that neutralize SARS-CoV-2 variants of concern
por: Almanza, Gonzalo, et al.
Publicado: (2022) -
Recombinant VLPs empower RBM peptides showing no immunogenicity in native SARS-COV-2 protein to elicit a robust neutralizing antibody response
por: Long, Qiong, et al.
Publicado: (2022) -
Predicting functional consequences of mutations using molecular interaction network features
por: Ozturk, Kivilcim, et al.
Publicado: (2021)