Fitness landscape of a dynamic RNA structure

RNA structures are dynamic. As a consequence, mutational effects can be hard to rationalize with reference to a single static native structure. We reasoned that deep mutational scanning experiments, which couple molecular function to fitness, should capture mutational effects across multiple conform...

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Detalles Bibliográficos
Autores principales: Soo, Valerie W. C., Swadling, Jacob B., Faure, Andre J., Warnecke, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877785/
https://www.ncbi.nlm.nih.gov/pubmed/33524037
http://dx.doi.org/10.1371/journal.pgen.1009353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877785/
https://www.ncbi.nlm.nih.gov/pubmed/33524037
http://dx.doi.org/10.1371/journal.pgen.1009353

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