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Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family
The first S-adenosyl methionine (SAM) degrading enzyme (SAMase) was discovered in bacteriophage T3, as a counter-defense against the bacterial restriction-modification system, and annotated as a SAM hydrolase forming 5’-methyl-thioadenosine (MTA) and L-homoserine. From environmental phages, we recen...
Autores principales: | Guo, Xiaohu, Söderholm, Annika, Kanchugal P, Sandesh, Isaksen, Geir V, Warsi, Omar, Eckhard, Ulrich, Trigüis, Silvia, Gogoll, Adolf, Jerlström-Hultqvist, Jon, Åqvist, Johan, Andersson, Dan I, Selmer, Maria |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877911/ https://www.ncbi.nlm.nih.gov/pubmed/33567250 http://dx.doi.org/10.7554/eLife.61818 |
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