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Time-course analysis reveals that corticosteroids resuscitate diminished CD8+ T cells in COVID-19: a retrospective cohort study

OBJECTIVE: To illustrate the effect of corticosteroids and heparin, respectively, on coronavirus disease 2019 (COVID-19) patients’ CD8+ T cells and D-dimer. METHODS: In this retrospective cohort study involving 866 participants diagnosed with COVID-19, patients were grouped by severity. Generalized...

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Autores principales: Ye, Fangzhou, Liu, Jing, Chen, Liangkai, Zhu, Bin, Yu, Li, Liang, Boyun, Xu, Ling, Li, Sumeng, Lu, Sihong, Fan, Lei, Yang, Dongliang, Zheng, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877944/
https://www.ncbi.nlm.nih.gov/pubmed/33183091
http://dx.doi.org/10.1080/07853890.2020.1851394
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author Ye, Fangzhou
Liu, Jing
Chen, Liangkai
Zhu, Bin
Yu, Li
Liang, Boyun
Xu, Ling
Li, Sumeng
Lu, Sihong
Fan, Lei
Yang, Dongliang
Zheng, Xin
author_facet Ye, Fangzhou
Liu, Jing
Chen, Liangkai
Zhu, Bin
Yu, Li
Liang, Boyun
Xu, Ling
Li, Sumeng
Lu, Sihong
Fan, Lei
Yang, Dongliang
Zheng, Xin
author_sort Ye, Fangzhou
collection PubMed
description OBJECTIVE: To illustrate the effect of corticosteroids and heparin, respectively, on coronavirus disease 2019 (COVID-19) patients’ CD8+ T cells and D-dimer. METHODS: In this retrospective cohort study involving 866 participants diagnosed with COVID-19, patients were grouped by severity. Generalized additive models were established to explore the time-course association of representative parameters of coagulation, inflammation and immunity. Segmented regression was performed to examine the influence of corticosteroids and heparin upon CD8+ T cell and D-dimer, respectively. RESULTS: There were 541 moderate, 169 severe and 156 critically ill patients involved in the study. Synchronous changes of levels of NLR, D-dimer and CD8+ T cell in critically ill patients were observed. Administration of methylprednisolone before 14 DFS compared with those after 14 DFS (β = 0.154%, 95% CI=(0, 0.302), p=.048) or a dose lower than 40 mg per day compared with those equals to 40 mg per day (β = 0.163%, 95% CI=(0.027, 0.295), p=.020) significantly increased the rising rate of CD8+ T cell in 14–56 DFS. CONCLUSIONS: The parameters of coagulation, inflammation and immunity were longitudinally correlated, and an early low-dose corticosteroid treatment accelerated the regaining of CD8+ T cell to help battle against SARS-Cov-2 in critical cases of COVID-19.
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spelling pubmed-78779442021-03-11 Time-course analysis reveals that corticosteroids resuscitate diminished CD8+ T cells in COVID-19: a retrospective cohort study Ye, Fangzhou Liu, Jing Chen, Liangkai Zhu, Bin Yu, Li Liang, Boyun Xu, Ling Li, Sumeng Lu, Sihong Fan, Lei Yang, Dongliang Zheng, Xin Ann Med Immunology OBJECTIVE: To illustrate the effect of corticosteroids and heparin, respectively, on coronavirus disease 2019 (COVID-19) patients’ CD8+ T cells and D-dimer. METHODS: In this retrospective cohort study involving 866 participants diagnosed with COVID-19, patients were grouped by severity. Generalized additive models were established to explore the time-course association of representative parameters of coagulation, inflammation and immunity. Segmented regression was performed to examine the influence of corticosteroids and heparin upon CD8+ T cell and D-dimer, respectively. RESULTS: There were 541 moderate, 169 severe and 156 critically ill patients involved in the study. Synchronous changes of levels of NLR, D-dimer and CD8+ T cell in critically ill patients were observed. Administration of methylprednisolone before 14 DFS compared with those after 14 DFS (β = 0.154%, 95% CI=(0, 0.302), p=.048) or a dose lower than 40 mg per day compared with those equals to 40 mg per day (β = 0.163%, 95% CI=(0.027, 0.295), p=.020) significantly increased the rising rate of CD8+ T cell in 14–56 DFS. CONCLUSIONS: The parameters of coagulation, inflammation and immunity were longitudinally correlated, and an early low-dose corticosteroid treatment accelerated the regaining of CD8+ T cell to help battle against SARS-Cov-2 in critical cases of COVID-19. Taylor & Francis 2021-01-11 /pmc/articles/PMC7877944/ /pubmed/33183091 http://dx.doi.org/10.1080/07853890.2020.1851394 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Immunology
Ye, Fangzhou
Liu, Jing
Chen, Liangkai
Zhu, Bin
Yu, Li
Liang, Boyun
Xu, Ling
Li, Sumeng
Lu, Sihong
Fan, Lei
Yang, Dongliang
Zheng, Xin
Time-course analysis reveals that corticosteroids resuscitate diminished CD8+ T cells in COVID-19: a retrospective cohort study
title Time-course analysis reveals that corticosteroids resuscitate diminished CD8+ T cells in COVID-19: a retrospective cohort study
title_full Time-course analysis reveals that corticosteroids resuscitate diminished CD8+ T cells in COVID-19: a retrospective cohort study
title_fullStr Time-course analysis reveals that corticosteroids resuscitate diminished CD8+ T cells in COVID-19: a retrospective cohort study
title_full_unstemmed Time-course analysis reveals that corticosteroids resuscitate diminished CD8+ T cells in COVID-19: a retrospective cohort study
title_short Time-course analysis reveals that corticosteroids resuscitate diminished CD8+ T cells in COVID-19: a retrospective cohort study
title_sort time-course analysis reveals that corticosteroids resuscitate diminished cd8+ t cells in covid-19: a retrospective cohort study
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877944/
https://www.ncbi.nlm.nih.gov/pubmed/33183091
http://dx.doi.org/10.1080/07853890.2020.1851394
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