The Effects of 3,4-methylenedioxymethamphetamine on Neurogenesis in the Hippocampus of Male Rats

INTRODUCTION: The administration of 3,4-methylenedioxymethamphetamine (MDMA) or ecstasy causes memory impairment, whereas neurogenesis improves memory and learning. Hence, this study evaluated the effects of MDMA on neurogenesis in the hippocampus of male rats. METHODS: Adult male Wistar rats receiv...

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Detalles Bibliográficos
Autores principales: Soleimani Asl, Sara, Ghasemi Moravej, Fahimeh, Kowsari, Golshad, Farhadi, Mohammad Hassan, Pourhaydar, Bagher, Ghasemi Hamidabadi, Hatef, Mehdizadeh, Mehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Neuroscience Society 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878031/
https://www.ncbi.nlm.nih.gov/pubmed/33613883
http://dx.doi.org/10.32598/bcn.9.10.420
Descripción
Sumario:INTRODUCTION: The administration of 3,4-methylenedioxymethamphetamine (MDMA) or ecstasy causes memory impairment, whereas neurogenesis improves memory and learning. Hence, this study evaluated the effects of MDMA on neurogenesis in the hippocampus of male rats. METHODS: Adult male Wistar rats received Intraperitoneal (IP) injections of MDMA (10 mg/ kg). We assessed nestin, sex-determining region Y-box 2 (Sox2), and NeuroD expressions according to the immunohistochemistry analyses. RESULTS: MDMA reduced the expressions of nestin, Sox2, and NeuroD compared with the control groups. The reduction in NeuroD expression was age-related. CONCLUSION: MDMA possibly has negative effects on neurogenesis, which specifically results from impaired survival of newborn cells.

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