Cargando…
An Energy-Resolved Optical Non-invasive Device Detects Essential Electrolyte Balance in Humans at Point-of-Care
Regular monitoring of electrolyte balance is essential for patients suffering from chronic kidney disease (CKD), particularly those undergoing dialysis. In the context of the recent COVID-19 pandemic, more severe forms of infection are observed in elderly individuals and patients having co-morbiditi...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Singapore
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878167/ https://www.ncbi.nlm.nih.gov/pubmed/35837575 http://dx.doi.org/10.1007/s41403-021-00204-3 |
_version_ | 1783650302179672064 |
---|---|
author | Bhattacharyya, Neha Singh, Soumendra Halder, Animesh Adhikari, Aniruddha Ghosh, Ria Shikha, Deep Tripathi, Santanu Kumar Mallick, Asim Kumar Mondal, Pulak Pal, Samir Kumar |
author_facet | Bhattacharyya, Neha Singh, Soumendra Halder, Animesh Adhikari, Aniruddha Ghosh, Ria Shikha, Deep Tripathi, Santanu Kumar Mallick, Asim Kumar Mondal, Pulak Pal, Samir Kumar |
author_sort | Bhattacharyya, Neha |
collection | PubMed |
description | Regular monitoring of electrolyte balance is essential for patients suffering from chronic kidney disease (CKD), particularly those undergoing dialysis. In the context of the recent COVID-19 pandemic, more severe forms of infection are observed in elderly individuals and patients having co-morbidities like CKD. The repeated blood tests for the monitoring of electrolyte balance predispose them not only to COVID-19 but also other to hospital-acquired infections (HAI). Therefore, a non-invasive method for easy detection of essential electrolyte (K(+) and Na(+)) levels is urgently needed. In this study, we developed an optical emission spectroscopy-based non-invasive device for simultaneous monitoring of salivary Na(+) and K(+) levels in a fast and reliable way. The device consisted of a closed spark chamber, micro-spectrometer, high voltage spark generator, electronic circuits, optical fiber, and an indigenously developed software based on the LabVIEW platform. The optical emission originating from the biological sample (i.e., saliva) due to recombination of ions energized by impingement of electrons returning from high voltage spark provides necessary information about the concentration of electrolytes. A small-scale clinical trial on 30 healthy human subjects shows the potential of the indigenously developed device in determining salivary Na( +) and K(+) concentration. The low-cost, portable, point-of-care device requires only 2 mL of sample, and can simultaneously measure 1.0–190.0 mM Na(+), and 1.0–270.9 mM K(+) . To our understanding, the present work will find its relevance in combating COVID-19 morbidities, along with regular CKD patient-care. |
format | Online Article Text |
id | pubmed-7878167 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-78781672021-02-16 An Energy-Resolved Optical Non-invasive Device Detects Essential Electrolyte Balance in Humans at Point-of-Care Bhattacharyya, Neha Singh, Soumendra Halder, Animesh Adhikari, Aniruddha Ghosh, Ria Shikha, Deep Tripathi, Santanu Kumar Mallick, Asim Kumar Mondal, Pulak Pal, Samir Kumar Trans Indian Natl. Acad. Eng. Original Article Regular monitoring of electrolyte balance is essential for patients suffering from chronic kidney disease (CKD), particularly those undergoing dialysis. In the context of the recent COVID-19 pandemic, more severe forms of infection are observed in elderly individuals and patients having co-morbidities like CKD. The repeated blood tests for the monitoring of electrolyte balance predispose them not only to COVID-19 but also other to hospital-acquired infections (HAI). Therefore, a non-invasive method for easy detection of essential electrolyte (K(+) and Na(+)) levels is urgently needed. In this study, we developed an optical emission spectroscopy-based non-invasive device for simultaneous monitoring of salivary Na(+) and K(+) levels in a fast and reliable way. The device consisted of a closed spark chamber, micro-spectrometer, high voltage spark generator, electronic circuits, optical fiber, and an indigenously developed software based on the LabVIEW platform. The optical emission originating from the biological sample (i.e., saliva) due to recombination of ions energized by impingement of electrons returning from high voltage spark provides necessary information about the concentration of electrolytes. A small-scale clinical trial on 30 healthy human subjects shows the potential of the indigenously developed device in determining salivary Na( +) and K(+) concentration. The low-cost, portable, point-of-care device requires only 2 mL of sample, and can simultaneously measure 1.0–190.0 mM Na(+), and 1.0–270.9 mM K(+) . To our understanding, the present work will find its relevance in combating COVID-19 morbidities, along with regular CKD patient-care. Springer Singapore 2021-02-11 2021 /pmc/articles/PMC7878167/ /pubmed/35837575 http://dx.doi.org/10.1007/s41403-021-00204-3 Text en © Indian National Academy of Engineering 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Original Article Bhattacharyya, Neha Singh, Soumendra Halder, Animesh Adhikari, Aniruddha Ghosh, Ria Shikha, Deep Tripathi, Santanu Kumar Mallick, Asim Kumar Mondal, Pulak Pal, Samir Kumar An Energy-Resolved Optical Non-invasive Device Detects Essential Electrolyte Balance in Humans at Point-of-Care |
title | An Energy-Resolved Optical Non-invasive Device Detects Essential Electrolyte Balance in Humans at Point-of-Care |
title_full | An Energy-Resolved Optical Non-invasive Device Detects Essential Electrolyte Balance in Humans at Point-of-Care |
title_fullStr | An Energy-Resolved Optical Non-invasive Device Detects Essential Electrolyte Balance in Humans at Point-of-Care |
title_full_unstemmed | An Energy-Resolved Optical Non-invasive Device Detects Essential Electrolyte Balance in Humans at Point-of-Care |
title_short | An Energy-Resolved Optical Non-invasive Device Detects Essential Electrolyte Balance in Humans at Point-of-Care |
title_sort | energy-resolved optical non-invasive device detects essential electrolyte balance in humans at point-of-care |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878167/ https://www.ncbi.nlm.nih.gov/pubmed/35837575 http://dx.doi.org/10.1007/s41403-021-00204-3 |
work_keys_str_mv | AT bhattacharyyaneha anenergyresolvedopticalnoninvasivedevicedetectsessentialelectrolytebalanceinhumansatpointofcare AT singhsoumendra anenergyresolvedopticalnoninvasivedevicedetectsessentialelectrolytebalanceinhumansatpointofcare AT halderanimesh anenergyresolvedopticalnoninvasivedevicedetectsessentialelectrolytebalanceinhumansatpointofcare AT adhikarianiruddha anenergyresolvedopticalnoninvasivedevicedetectsessentialelectrolytebalanceinhumansatpointofcare AT ghoshria anenergyresolvedopticalnoninvasivedevicedetectsessentialelectrolytebalanceinhumansatpointofcare AT shikhadeep anenergyresolvedopticalnoninvasivedevicedetectsessentialelectrolytebalanceinhumansatpointofcare AT tripathisantanukumar anenergyresolvedopticalnoninvasivedevicedetectsessentialelectrolytebalanceinhumansatpointofcare AT mallickasimkumar anenergyresolvedopticalnoninvasivedevicedetectsessentialelectrolytebalanceinhumansatpointofcare AT mondalpulak anenergyresolvedopticalnoninvasivedevicedetectsessentialelectrolytebalanceinhumansatpointofcare AT palsamirkumar anenergyresolvedopticalnoninvasivedevicedetectsessentialelectrolytebalanceinhumansatpointofcare AT bhattacharyyaneha energyresolvedopticalnoninvasivedevicedetectsessentialelectrolytebalanceinhumansatpointofcare AT singhsoumendra energyresolvedopticalnoninvasivedevicedetectsessentialelectrolytebalanceinhumansatpointofcare AT halderanimesh energyresolvedopticalnoninvasivedevicedetectsessentialelectrolytebalanceinhumansatpointofcare AT adhikarianiruddha energyresolvedopticalnoninvasivedevicedetectsessentialelectrolytebalanceinhumansatpointofcare AT ghoshria energyresolvedopticalnoninvasivedevicedetectsessentialelectrolytebalanceinhumansatpointofcare AT shikhadeep energyresolvedopticalnoninvasivedevicedetectsessentialelectrolytebalanceinhumansatpointofcare AT tripathisantanukumar energyresolvedopticalnoninvasivedevicedetectsessentialelectrolytebalanceinhumansatpointofcare AT mallickasimkumar energyresolvedopticalnoninvasivedevicedetectsessentialelectrolytebalanceinhumansatpointofcare AT mondalpulak energyresolvedopticalnoninvasivedevicedetectsessentialelectrolytebalanceinhumansatpointofcare AT palsamirkumar energyresolvedopticalnoninvasivedevicedetectsessentialelectrolytebalanceinhumansatpointofcare |