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An Energy-Resolved Optical Non-invasive Device Detects Essential Electrolyte Balance in Humans at Point-of-Care

Regular monitoring of electrolyte balance is essential for patients suffering from chronic kidney disease (CKD), particularly those undergoing dialysis. In the context of the recent COVID-19 pandemic, more severe forms of infection are observed in elderly individuals and patients having co-morbiditi...

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Autores principales: Bhattacharyya, Neha, Singh, Soumendra, Halder, Animesh, Adhikari, Aniruddha, Ghosh, Ria, Shikha, Deep, Tripathi, Santanu Kumar, Mallick, Asim Kumar, Mondal, Pulak, Pal, Samir Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878167/
https://www.ncbi.nlm.nih.gov/pubmed/35837575
http://dx.doi.org/10.1007/s41403-021-00204-3
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author Bhattacharyya, Neha
Singh, Soumendra
Halder, Animesh
Adhikari, Aniruddha
Ghosh, Ria
Shikha, Deep
Tripathi, Santanu Kumar
Mallick, Asim Kumar
Mondal, Pulak
Pal, Samir Kumar
author_facet Bhattacharyya, Neha
Singh, Soumendra
Halder, Animesh
Adhikari, Aniruddha
Ghosh, Ria
Shikha, Deep
Tripathi, Santanu Kumar
Mallick, Asim Kumar
Mondal, Pulak
Pal, Samir Kumar
author_sort Bhattacharyya, Neha
collection PubMed
description Regular monitoring of electrolyte balance is essential for patients suffering from chronic kidney disease (CKD), particularly those undergoing dialysis. In the context of the recent COVID-19 pandemic, more severe forms of infection are observed in elderly individuals and patients having co-morbidities like CKD. The repeated blood tests for the monitoring of electrolyte balance predispose them not only to COVID-19 but also other to hospital-acquired infections (HAI). Therefore, a non-invasive method for easy detection of essential electrolyte (K(+) and Na(+)) levels is urgently needed. In this study, we developed an optical emission spectroscopy-based non-invasive device for simultaneous monitoring of salivary Na(+) and K(+) levels in a fast and reliable way. The device consisted of a closed spark chamber, micro-spectrometer, high voltage spark generator, electronic circuits, optical fiber, and an indigenously developed software based on the LabVIEW platform. The optical emission originating from the biological sample (i.e., saliva) due to recombination of ions energized by impingement of electrons returning from high voltage spark provides necessary information about the concentration of electrolytes. A small-scale clinical trial on 30 healthy human subjects shows the potential of the indigenously developed device in determining salivary Na( +) and K(+) concentration. The low-cost, portable, point-of-care device requires only 2 mL of sample, and can simultaneously measure 1.0–190.0 mM Na(+), and 1.0–270.9 mM K(+) . To our understanding, the present work will find its relevance in combating COVID-19 morbidities, along with regular CKD patient-care.
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spelling pubmed-78781672021-02-16 An Energy-Resolved Optical Non-invasive Device Detects Essential Electrolyte Balance in Humans at Point-of-Care Bhattacharyya, Neha Singh, Soumendra Halder, Animesh Adhikari, Aniruddha Ghosh, Ria Shikha, Deep Tripathi, Santanu Kumar Mallick, Asim Kumar Mondal, Pulak Pal, Samir Kumar Trans Indian Natl. Acad. Eng. Original Article Regular monitoring of electrolyte balance is essential for patients suffering from chronic kidney disease (CKD), particularly those undergoing dialysis. In the context of the recent COVID-19 pandemic, more severe forms of infection are observed in elderly individuals and patients having co-morbidities like CKD. The repeated blood tests for the monitoring of electrolyte balance predispose them not only to COVID-19 but also other to hospital-acquired infections (HAI). Therefore, a non-invasive method for easy detection of essential electrolyte (K(+) and Na(+)) levels is urgently needed. In this study, we developed an optical emission spectroscopy-based non-invasive device for simultaneous monitoring of salivary Na(+) and K(+) levels in a fast and reliable way. The device consisted of a closed spark chamber, micro-spectrometer, high voltage spark generator, electronic circuits, optical fiber, and an indigenously developed software based on the LabVIEW platform. The optical emission originating from the biological sample (i.e., saliva) due to recombination of ions energized by impingement of electrons returning from high voltage spark provides necessary information about the concentration of electrolytes. A small-scale clinical trial on 30 healthy human subjects shows the potential of the indigenously developed device in determining salivary Na( +) and K(+) concentration. The low-cost, portable, point-of-care device requires only 2 mL of sample, and can simultaneously measure 1.0–190.0 mM Na(+), and 1.0–270.9 mM K(+) . To our understanding, the present work will find its relevance in combating COVID-19 morbidities, along with regular CKD patient-care. Springer Singapore 2021-02-11 2021 /pmc/articles/PMC7878167/ /pubmed/35837575 http://dx.doi.org/10.1007/s41403-021-00204-3 Text en © Indian National Academy of Engineering 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article
Bhattacharyya, Neha
Singh, Soumendra
Halder, Animesh
Adhikari, Aniruddha
Ghosh, Ria
Shikha, Deep
Tripathi, Santanu Kumar
Mallick, Asim Kumar
Mondal, Pulak
Pal, Samir Kumar
An Energy-Resolved Optical Non-invasive Device Detects Essential Electrolyte Balance in Humans at Point-of-Care
title An Energy-Resolved Optical Non-invasive Device Detects Essential Electrolyte Balance in Humans at Point-of-Care
title_full An Energy-Resolved Optical Non-invasive Device Detects Essential Electrolyte Balance in Humans at Point-of-Care
title_fullStr An Energy-Resolved Optical Non-invasive Device Detects Essential Electrolyte Balance in Humans at Point-of-Care
title_full_unstemmed An Energy-Resolved Optical Non-invasive Device Detects Essential Electrolyte Balance in Humans at Point-of-Care
title_short An Energy-Resolved Optical Non-invasive Device Detects Essential Electrolyte Balance in Humans at Point-of-Care
title_sort energy-resolved optical non-invasive device detects essential electrolyte balance in humans at point-of-care
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878167/
https://www.ncbi.nlm.nih.gov/pubmed/35837575
http://dx.doi.org/10.1007/s41403-021-00204-3
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