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Monitoring of tisagenlecleucel transgene DNA using a quantitative polymerase chain reaction assay

Chimeric antigen receptor (CAR)-T cell therapies reprogram T cells to engage and eliminate cancer cells. Patients’ T cells are transduced in vitro using lentiviral or retroviral vectors containing a CAR transgene. Following infusion, CAR-T cells expand in vivo and may persist in the peripheral blood...

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Detalles Bibliográficos
Autores principales:	Davis, Lisa, Riccitelli, Nathan, Valencia, Nancy, Ch’en, Irene L., Tangri, Shabnam, Brogdon, Jennifer L., Kalfoglou, Creton, Mueller, Karen Thudium, Pollner, Reinhold
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878179/ https://www.ncbi.nlm.nih.gov/pubmed/33614827 http://dx.doi.org/10.1016/j.omtm.2020.12.002

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