Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia

BACKGROUND: Acute lymphoblastic leukaemia with mixed lineage leukaemia gene rearrangement (MLL-ALL) frequently affects infants and is associated with a poor prognosis. Primary refractory and relapsed disease due to resistance to glucocorticoids (GCs) remains a substantial hurdle to improving clinica...

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Detalles Bibliográficos
Autores principales: de Groot, Anne P., Saito, Yoriko, Kawakami, Eiryo, Hashimoto, Mari, Aoki, Yuki, Ono, Rintaro, Ogahara, Ikuko, Fujiki, Saera, Kaneko, Akiko, Sato, Kaori, Kajita, Hiroshi, Watanabe, Takashi, Takagi, Masatoshi, Tomizawa, Daisuke, Koh, Katsuyoshi, Eguchi, Mariko, Ishii, Eiichi, Ohara, Osamu, Shultz, Leonard D., Mizutani, Shuki, Ishikawa, Fumihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878180/
https://www.ncbi.nlm.nih.gov/pubmed/33581643
http://dx.doi.org/10.1016/j.ebiom.2021.103235

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