Enhanced antitumor efficacy of a novel oncolytic vaccinia virus encoding a fully monoclonal antibody against T-cell immunoglobulin and ITIM domain (TIGIT)

BACKGROUND: Oncolytic virotherapy with vaccinia virus (VV) can lead to effective anti-tumor immunity by turning “cold” tumors into “hot” tumors. However, its therapeutic potential is affected by the tumor's local immunosuppressive tumor microenvironment (TME). Therefore, it is necessary to expl...

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Detalles Bibliográficos
Autores principales: Zuo, Shuguang, Wei, Min, He, Bohao, Chen, Anxian, Wang, Shiqun, Kong, Lingkai, Zhang, Yenan, Meng, Gang, Xu, Tiancheng, Wu, Jingyi, Yang, Fuming, Zhang, Hailin, Wang, Shibing, Guo, Ciliang, Wu, Junhua, Dong, Jie, Wei, Jiwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878184/
https://www.ncbi.nlm.nih.gov/pubmed/33581644
http://dx.doi.org/10.1016/j.ebiom.2021.103240

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