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Cigarette smoke-induced LKB1/AMPK pathway deficiency reduces EGFR TKI sensitivity in NSCLC

Smoker patients with non-small cell lung cancer (NSCLC) have poorer prognosis and survival than those without smoking history. However, the mechanisms underlying the low response rate of those patients to EGFR tyrosine kinase inhibitors (TKIs) are not well understood. Here we report that exposure to...

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Detalles Bibliográficos
Autores principales:	Cheng, Fang-Ju, Chen, Chia-Hung, Tsai, Wen-Chen, Wang, Bo-Wei, Yu, Meng-Chieh, Hsia, Te-Chun, Wei, Ya-Ling, Hsiao, Yu-Chun, Hu, Dai-Wei, Ho, Chien-Yi, Li, Tzong-Shiun, Wu, Chun-Yi, Chou, Wen-Yu, Yu, Yung-Luen, Tang, Chih-Hsin, Chen, Chih-Yi, Chen, Chuan-Mu, Hsu, Jennifer L., Chen, Hsiao-Fan, Chen, Yeh, Tu, Chih-Yen, Hung, Mien-Chie, Huang, Wei-Chien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878190/ https://www.ncbi.nlm.nih.gov/pubmed/33335306 http://dx.doi.org/10.1038/s41388-020-01597-1

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