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Routine panendoscopy in oral squamous cell cancer patients: mandatory or facultative?

OBJECTIVES: This study investigated benefits of routine panendoscopy in staging of oral squamous cell cancer patients. MATERIALS AND METHODS: From 2013 to 2017, 194 oral squamous cell cancer patients were staged. Reports of routine flexible panendoscopy including oropharyngolaryngoscopy, bronchoscop...

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Autores principales: Valentin, Anthony, Goetz, Martin, Hetzel, Juergen, Reinert, Siegmar, Hoefert, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878265/
https://www.ncbi.nlm.nih.gov/pubmed/32607829
http://dx.doi.org/10.1007/s00784-020-03429-8
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author Valentin, Anthony
Goetz, Martin
Hetzel, Juergen
Reinert, Siegmar
Hoefert, Sebastian
author_facet Valentin, Anthony
Goetz, Martin
Hetzel, Juergen
Reinert, Siegmar
Hoefert, Sebastian
author_sort Valentin, Anthony
collection PubMed
description OBJECTIVES: This study investigated benefits of routine panendoscopy in staging of oral squamous cell cancer patients. MATERIALS AND METHODS: From 2013 to 2017, 194 oral squamous cell cancer patients were staged. Reports of routine flexible panendoscopy including oropharyngolaryngoscopy, bronchoscopy, and esophagogastroduodenoscopy were retrospectively analyzed for diagnoses of inflammation and second primary malignancies (carcinoma in situ or cancer) and compared to results of computed tomography. The effects of alcohol and tobacco history of 142 patients were assessed. RESULTS: Overall, a second primary malignancy was detected in seven patients. In four patients this discovery was only found by panendoscopy. One invasive carcinoma (esophagus) was detected as well as three carcinoma in situ. The second primary malignancies were located in the lung (3), esophagus (3), and stomach (1). In one patient index tumor therapy was modified after panendoscopy. Upper gastrointestinal inflammation was present in 73.2% of patients and 61.9% required treatment. About 91.8% of bronchoscopies and 34.5% of panendoscopies were without therapeutic consequences. Patients with higher risk from smoking were more likely to benefit from panendoscopy and to have a Helicobacter pylori infection. CONCLUSION: We do not recommend routine panendoscopy for all oral squamous cell cancer patients. Esophagogastroduodenoscopy benefitted smoking patients primarily concerning the secondary diagnosis of inflammation of the upper digestive tract. Selective bronchoscopy, esophagogastroduodenoscopy, and oropharyngolaryngoscopy should be performed if clinical examination or medical history indicates risks for additional malignancies of the upper aerodigestive tract. CLINICAL RELEVANCE: Routine panendoscopy is not recommended in all, especially not in low-risk oral cancer patients like non-smokers and non-drinkers.
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spelling pubmed-78782652021-02-22 Routine panendoscopy in oral squamous cell cancer patients: mandatory or facultative? Valentin, Anthony Goetz, Martin Hetzel, Juergen Reinert, Siegmar Hoefert, Sebastian Clin Oral Investig Original Article OBJECTIVES: This study investigated benefits of routine panendoscopy in staging of oral squamous cell cancer patients. MATERIALS AND METHODS: From 2013 to 2017, 194 oral squamous cell cancer patients were staged. Reports of routine flexible panendoscopy including oropharyngolaryngoscopy, bronchoscopy, and esophagogastroduodenoscopy were retrospectively analyzed for diagnoses of inflammation and second primary malignancies (carcinoma in situ or cancer) and compared to results of computed tomography. The effects of alcohol and tobacco history of 142 patients were assessed. RESULTS: Overall, a second primary malignancy was detected in seven patients. In four patients this discovery was only found by panendoscopy. One invasive carcinoma (esophagus) was detected as well as three carcinoma in situ. The second primary malignancies were located in the lung (3), esophagus (3), and stomach (1). In one patient index tumor therapy was modified after panendoscopy. Upper gastrointestinal inflammation was present in 73.2% of patients and 61.9% required treatment. About 91.8% of bronchoscopies and 34.5% of panendoscopies were without therapeutic consequences. Patients with higher risk from smoking were more likely to benefit from panendoscopy and to have a Helicobacter pylori infection. CONCLUSION: We do not recommend routine panendoscopy for all oral squamous cell cancer patients. Esophagogastroduodenoscopy benefitted smoking patients primarily concerning the secondary diagnosis of inflammation of the upper digestive tract. Selective bronchoscopy, esophagogastroduodenoscopy, and oropharyngolaryngoscopy should be performed if clinical examination or medical history indicates risks for additional malignancies of the upper aerodigestive tract. CLINICAL RELEVANCE: Routine panendoscopy is not recommended in all, especially not in low-risk oral cancer patients like non-smokers and non-drinkers. Springer Berlin Heidelberg 2020-07-01 2021 /pmc/articles/PMC7878265/ /pubmed/32607829 http://dx.doi.org/10.1007/s00784-020-03429-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Valentin, Anthony
Goetz, Martin
Hetzel, Juergen
Reinert, Siegmar
Hoefert, Sebastian
Routine panendoscopy in oral squamous cell cancer patients: mandatory or facultative?
title Routine panendoscopy in oral squamous cell cancer patients: mandatory or facultative?
title_full Routine panendoscopy in oral squamous cell cancer patients: mandatory or facultative?
title_fullStr Routine panendoscopy in oral squamous cell cancer patients: mandatory or facultative?
title_full_unstemmed Routine panendoscopy in oral squamous cell cancer patients: mandatory or facultative?
title_short Routine panendoscopy in oral squamous cell cancer patients: mandatory or facultative?
title_sort routine panendoscopy in oral squamous cell cancer patients: mandatory or facultative?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878265/
https://www.ncbi.nlm.nih.gov/pubmed/32607829
http://dx.doi.org/10.1007/s00784-020-03429-8
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