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The Role of PTX3 in Mineralization Processes and Aging-Related Bone Diseases

The Long Pentraxin 3 (PTX3) is a multifunctional glycoprotein released by peripheral blood leukocytes and myeloid dendritic cells in response to primary pro-inflammatory stimuli, that acts as a non-redundant component of the humoral arm of innate immunity. In addition to the primary role in the acut...

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Autores principales: Tarantino, Umberto, Greggi, Chiara, Cariati, Ida, Visconti, Virginia Veronica, Gasparini, Monica, Cateni, Marco, Gasbarra, Elena, Botta, Annalisa, Salustri, Antonietta, Scimeca, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878364/
https://www.ncbi.nlm.nih.gov/pubmed/33584725
http://dx.doi.org/10.3389/fimmu.2020.622772
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author Tarantino, Umberto
Greggi, Chiara
Cariati, Ida
Visconti, Virginia Veronica
Gasparini, Monica
Cateni, Marco
Gasbarra, Elena
Botta, Annalisa
Salustri, Antonietta
Scimeca, Manuel
author_facet Tarantino, Umberto
Greggi, Chiara
Cariati, Ida
Visconti, Virginia Veronica
Gasparini, Monica
Cateni, Marco
Gasbarra, Elena
Botta, Annalisa
Salustri, Antonietta
Scimeca, Manuel
author_sort Tarantino, Umberto
collection PubMed
description The Long Pentraxin 3 (PTX3) is a multifunctional glycoprotein released by peripheral blood leukocytes and myeloid dendritic cells in response to primary pro-inflammatory stimuli, that acts as a non-redundant component of the humoral arm of innate immunity. In addition to the primary role in the acute inflammatory response, PTX3 seems to be involved in other physiological and pathological processes. Indeed, PTX3 seems to play a pivotal role in the deposition and remodeling of bone matrix during the mineralization process, promoting osteoblasts differentiation and activity. Recently, PTX3 was seen to be involved in the ectopic calcifications’ formation in breast cancer disease. In this regard, it has been observed that breast cancer tumors characterized by high expression of PTX3 and high amount of Breast Osteoblast Like Cells (BOLCs) showed several Hydroxyapatite (HA) microcalcifications, suggesting a likely role for PTX3 in differentiation and osteoblastic activity in both bone and extra-bone sites. Furthermore, given its involvement in bone metabolism, several studies agree with the definition of PTX3 as a molecule significantly involved in the pathogenesis of age-related bone diseases, such as osteoporosis, both in mice and humans. Recent results suggest that genetic and epigenetic mechanisms acting on PTX3 gene are also involved in the progression of these diseases. Based on these evidences, the aim of our systemic review was to offer an overview of the variety of biological processes in which PTX3 is involved, focusing on bone mineralization, both in a physiological and pathological context.
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spelling pubmed-78783642021-02-13 The Role of PTX3 in Mineralization Processes and Aging-Related Bone Diseases Tarantino, Umberto Greggi, Chiara Cariati, Ida Visconti, Virginia Veronica Gasparini, Monica Cateni, Marco Gasbarra, Elena Botta, Annalisa Salustri, Antonietta Scimeca, Manuel Front Immunol Immunology The Long Pentraxin 3 (PTX3) is a multifunctional glycoprotein released by peripheral blood leukocytes and myeloid dendritic cells in response to primary pro-inflammatory stimuli, that acts as a non-redundant component of the humoral arm of innate immunity. In addition to the primary role in the acute inflammatory response, PTX3 seems to be involved in other physiological and pathological processes. Indeed, PTX3 seems to play a pivotal role in the deposition and remodeling of bone matrix during the mineralization process, promoting osteoblasts differentiation and activity. Recently, PTX3 was seen to be involved in the ectopic calcifications’ formation in breast cancer disease. In this regard, it has been observed that breast cancer tumors characterized by high expression of PTX3 and high amount of Breast Osteoblast Like Cells (BOLCs) showed several Hydroxyapatite (HA) microcalcifications, suggesting a likely role for PTX3 in differentiation and osteoblastic activity in both bone and extra-bone sites. Furthermore, given its involvement in bone metabolism, several studies agree with the definition of PTX3 as a molecule significantly involved in the pathogenesis of age-related bone diseases, such as osteoporosis, both in mice and humans. Recent results suggest that genetic and epigenetic mechanisms acting on PTX3 gene are also involved in the progression of these diseases. Based on these evidences, the aim of our systemic review was to offer an overview of the variety of biological processes in which PTX3 is involved, focusing on bone mineralization, both in a physiological and pathological context. Frontiers Media S.A. 2021-01-29 /pmc/articles/PMC7878364/ /pubmed/33584725 http://dx.doi.org/10.3389/fimmu.2020.622772 Text en Copyright © 2021 Tarantino, Greggi, Cariati, Visconti, Gasparini, Cateni, Gasbarra, Botta, Salustri and Scimeca http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Tarantino, Umberto
Greggi, Chiara
Cariati, Ida
Visconti, Virginia Veronica
Gasparini, Monica
Cateni, Marco
Gasbarra, Elena
Botta, Annalisa
Salustri, Antonietta
Scimeca, Manuel
The Role of PTX3 in Mineralization Processes and Aging-Related Bone Diseases
title The Role of PTX3 in Mineralization Processes and Aging-Related Bone Diseases
title_full The Role of PTX3 in Mineralization Processes and Aging-Related Bone Diseases
title_fullStr The Role of PTX3 in Mineralization Processes and Aging-Related Bone Diseases
title_full_unstemmed The Role of PTX3 in Mineralization Processes and Aging-Related Bone Diseases
title_short The Role of PTX3 in Mineralization Processes and Aging-Related Bone Diseases
title_sort role of ptx3 in mineralization processes and aging-related bone diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878364/
https://www.ncbi.nlm.nih.gov/pubmed/33584725
http://dx.doi.org/10.3389/fimmu.2020.622772
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