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Myosin Light Chain 9/12 Regulates the Pathogenesis of Inflammatory Bowel Disease
The numbers of patients with inflammatory bowel disease (IBD), such as ulcerative colitis (UC) and Crohn’s disease (CD), have been increasing over time, worldwide; however, the pathogenesis of IBD is multifactorial and has not been fully understood. Myosin light chain 9 and 12a and 12b (Myl9/12) are...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878395/ https://www.ncbi.nlm.nih.gov/pubmed/33584659 http://dx.doi.org/10.3389/fimmu.2020.594297 |
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author | Yokoyama, Masaya Kimura, Motoko Y. Ito, Toshihiro Hayashizaki, Koji Endo, Yukihiro Wang, Yangsong Yagi, Ryoji Nakagawa, Tomoo Kato, Naoya Matsubara, Hisahiro Nakayama, Toshinori |
author_facet | Yokoyama, Masaya Kimura, Motoko Y. Ito, Toshihiro Hayashizaki, Koji Endo, Yukihiro Wang, Yangsong Yagi, Ryoji Nakagawa, Tomoo Kato, Naoya Matsubara, Hisahiro Nakayama, Toshinori |
author_sort | Yokoyama, Masaya |
collection | PubMed |
description | The numbers of patients with inflammatory bowel disease (IBD), such as ulcerative colitis (UC) and Crohn’s disease (CD), have been increasing over time, worldwide; however, the pathogenesis of IBD is multifactorial and has not been fully understood. Myosin light chain 9 and 12a and 12b (Myl9/12) are known as ligands of the CD69 molecule. They create “Myl9 nets” that are often detected in inflamed site, which play a crucial role in regulating the recruitment and retention of CD69-expressing effector cells in inflamed tissues. We demonstrated the strong expression of Myl9/12 in the inflamed gut of IBD patients and mice with DSS-induced colitis. The administration of anti-Myl9/12 Ab to mice with DSS-induced colitis ameliorated the inflammation and prolonged their survival. The plasma Myl9 levels in the patients with active UC and CD were significantly higher than those in patients with disease remission, and may depict the disease severity of IBD patients, especially those with UC. Thus, our results indicate that Myl9/12 are involved in the pathogenesis of IBD, and are likely to be a new therapeutic target for patients suffering from IBD. |
format | Online Article Text |
id | pubmed-7878395 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78783952021-02-13 Myosin Light Chain 9/12 Regulates the Pathogenesis of Inflammatory Bowel Disease Yokoyama, Masaya Kimura, Motoko Y. Ito, Toshihiro Hayashizaki, Koji Endo, Yukihiro Wang, Yangsong Yagi, Ryoji Nakagawa, Tomoo Kato, Naoya Matsubara, Hisahiro Nakayama, Toshinori Front Immunol Immunology The numbers of patients with inflammatory bowel disease (IBD), such as ulcerative colitis (UC) and Crohn’s disease (CD), have been increasing over time, worldwide; however, the pathogenesis of IBD is multifactorial and has not been fully understood. Myosin light chain 9 and 12a and 12b (Myl9/12) are known as ligands of the CD69 molecule. They create “Myl9 nets” that are often detected in inflamed site, which play a crucial role in regulating the recruitment and retention of CD69-expressing effector cells in inflamed tissues. We demonstrated the strong expression of Myl9/12 in the inflamed gut of IBD patients and mice with DSS-induced colitis. The administration of anti-Myl9/12 Ab to mice with DSS-induced colitis ameliorated the inflammation and prolonged their survival. The plasma Myl9 levels in the patients with active UC and CD were significantly higher than those in patients with disease remission, and may depict the disease severity of IBD patients, especially those with UC. Thus, our results indicate that Myl9/12 are involved in the pathogenesis of IBD, and are likely to be a new therapeutic target for patients suffering from IBD. Frontiers Media S.A. 2021-01-29 /pmc/articles/PMC7878395/ /pubmed/33584659 http://dx.doi.org/10.3389/fimmu.2020.594297 Text en Copyright © 2021 Yokoyama, Kimura, Ito, Hayashizaki, Endo, Wang, Yagi, Nakagawa, Kato, Matsubara and Nakayama http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Yokoyama, Masaya Kimura, Motoko Y. Ito, Toshihiro Hayashizaki, Koji Endo, Yukihiro Wang, Yangsong Yagi, Ryoji Nakagawa, Tomoo Kato, Naoya Matsubara, Hisahiro Nakayama, Toshinori Myosin Light Chain 9/12 Regulates the Pathogenesis of Inflammatory Bowel Disease |
title | Myosin Light Chain 9/12 Regulates the Pathogenesis of Inflammatory Bowel Disease |
title_full | Myosin Light Chain 9/12 Regulates the Pathogenesis of Inflammatory Bowel Disease |
title_fullStr | Myosin Light Chain 9/12 Regulates the Pathogenesis of Inflammatory Bowel Disease |
title_full_unstemmed | Myosin Light Chain 9/12 Regulates the Pathogenesis of Inflammatory Bowel Disease |
title_short | Myosin Light Chain 9/12 Regulates the Pathogenesis of Inflammatory Bowel Disease |
title_sort | myosin light chain 9/12 regulates the pathogenesis of inflammatory bowel disease |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878395/ https://www.ncbi.nlm.nih.gov/pubmed/33584659 http://dx.doi.org/10.3389/fimmu.2020.594297 |
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