Cold sensitivity of the SARS-CoV-2 spike ectodomain

The SARS-CoV-2 spike (S) protein, a primary target for COVID-19 vaccine development, presents its Receptor Binding Domain in two conformations, receptor-accessible “up” or receptor-inaccessible “down” states. Here we report that the commonly used stabilized S ectodomain construct “2P” is sensitive t...

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Detalles Bibliográficos
Autores principales: Edwards, Robert J, Mansouri, Katayoun, Stalls, Victoria, Manne, Kartik, Watts, Brian, Parks, Rob, Janowska, Katarzyna, Gobeil, Sophie M. C., Kopp, Megan, Li, Dapeng, Lu, Xiaozhi, Mu, Zekun, Deyton, Margaret, Oguin, Thomas H, Sprenz, Jordan, Williams, Wilton, Saunders, Kevin O., Montefiori, David, Sempowski, Gregory D., Henderson, Rory, Alam, S. Munir, Haynes, Barton F., Acharya, Priyamvada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878407/
https://www.ncbi.nlm.nih.gov/pubmed/33402708
http://dx.doi.org/10.1038/s41594-020-00547-5

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