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Gene delivery corrects N-acetylglutamate synthase deficiency and enables insights in the physiological impact of L-arginine activation of N-acetylglutamate synthase

The urea cycle protects the central nervous system from ammonia toxicity by converting ammonia to urea. N-acetylglutamate synthase (NAGS) catalyzes formation of N-acetylglutamate, an essential allosteric activator of carbamylphosphate synthetase 1. Enzymatic activity of mammalian NAGS doubles in the...

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Detalles Bibliográficos
Autores principales:	Sonaimuthu, P., Senkevitch, E., Haskins, N., Uapinyoying, P., McNutt, M., Morizono, H., Tuchman, M., Caldovic, L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878489/ https://www.ncbi.nlm.nih.gov/pubmed/33574402 http://dx.doi.org/10.1038/s41598-021-82994-8

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