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Epigallocatechin Gallate During Dietary Restriction — Potential Mechanisms of Enhanced Liver Injury

Green tea extract (GTE) is popular in weight loss, and epigallocatechin gallate (EGCG) is considered as the main active component. However, GTE is the primary cause of herbal and dietary supplement-induced liver injury in the United States. Whether there is a greater risk of liver injury when EGCG i...

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Autores principales: Shi, Zhuo, Zhu, Jing-xiao, Guo, Yu-ming, Niu, Ming, Zhang, Le, Tu, Can, Huang, Ying, Li, Peng-yan, Zhao, Xu, Zhang, Zi-teng, Bai, Zhao-fang, Zhang, Guang-qin, Lu, Yang, Xiao, Xiao-he, Wang, Jia-bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878556/
https://www.ncbi.nlm.nih.gov/pubmed/33584288
http://dx.doi.org/10.3389/fphar.2020.609378
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author Shi, Zhuo
Zhu, Jing-xiao
Guo, Yu-ming
Niu, Ming
Zhang, Le
Tu, Can
Huang, Ying
Li, Peng-yan
Zhao, Xu
Zhang, Zi-teng
Bai, Zhao-fang
Zhang, Guang-qin
Lu, Yang
Xiao, Xiao-he
Wang, Jia-bo
author_facet Shi, Zhuo
Zhu, Jing-xiao
Guo, Yu-ming
Niu, Ming
Zhang, Le
Tu, Can
Huang, Ying
Li, Peng-yan
Zhao, Xu
Zhang, Zi-teng
Bai, Zhao-fang
Zhang, Guang-qin
Lu, Yang
Xiao, Xiao-he
Wang, Jia-bo
author_sort Shi, Zhuo
collection PubMed
description Green tea extract (GTE) is popular in weight loss, and epigallocatechin gallate (EGCG) is considered as the main active component. However, GTE is the primary cause of herbal and dietary supplement-induced liver injury in the United States. Whether there is a greater risk of liver injury when EGCG is consumed during dieting for weight loss has not been previously reported. This study found for the first time that EGCG could induce enhanced lipid metabolism pathways, suggesting that EGCG had the so-called “fat burning” effect, although EGCG did not cause liver injury at doses of 400 or 800 mg/kg in normal mice. Intriguingly, we found that EGCG caused dose-dependent hepatotoxicity on mice under dietary restriction, suggesting the potential combination effects of dietary restriction and EGCG. The combination effect between EGCG and dietary restriction led to overactivation of linoleic acid and arachidonic acid oxidation pathways, significantly increasing the accumulation of pro-inflammatory lipid metabolites and thus mediating liver injury. We also found that the disruption of Lands’ cycle and sphingomyelin-ceramides cycle and the high expression of taurine-conjugated bile acids were important metabolomic characteristics in EGCG-induced liver injury under dietary restriction. This original discovery suggests that people should not go on a diet while consuming EGCG for weight loss; otherwise the risk of liver injury will be significantly increased. This discovery provides new evidence for understanding the “drug-host” interaction hypothesis of drug hepatotoxicity and provides experimental reference for clinical safe use of green tea-related dietary supplements.
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spelling pubmed-78785562021-02-13 Epigallocatechin Gallate During Dietary Restriction — Potential Mechanisms of Enhanced Liver Injury Shi, Zhuo Zhu, Jing-xiao Guo, Yu-ming Niu, Ming Zhang, Le Tu, Can Huang, Ying Li, Peng-yan Zhao, Xu Zhang, Zi-teng Bai, Zhao-fang Zhang, Guang-qin Lu, Yang Xiao, Xiao-he Wang, Jia-bo Front Pharmacol Pharmacology Green tea extract (GTE) is popular in weight loss, and epigallocatechin gallate (EGCG) is considered as the main active component. However, GTE is the primary cause of herbal and dietary supplement-induced liver injury in the United States. Whether there is a greater risk of liver injury when EGCG is consumed during dieting for weight loss has not been previously reported. This study found for the first time that EGCG could induce enhanced lipid metabolism pathways, suggesting that EGCG had the so-called “fat burning” effect, although EGCG did not cause liver injury at doses of 400 or 800 mg/kg in normal mice. Intriguingly, we found that EGCG caused dose-dependent hepatotoxicity on mice under dietary restriction, suggesting the potential combination effects of dietary restriction and EGCG. The combination effect between EGCG and dietary restriction led to overactivation of linoleic acid and arachidonic acid oxidation pathways, significantly increasing the accumulation of pro-inflammatory lipid metabolites and thus mediating liver injury. We also found that the disruption of Lands’ cycle and sphingomyelin-ceramides cycle and the high expression of taurine-conjugated bile acids were important metabolomic characteristics in EGCG-induced liver injury under dietary restriction. This original discovery suggests that people should not go on a diet while consuming EGCG for weight loss; otherwise the risk of liver injury will be significantly increased. This discovery provides new evidence for understanding the “drug-host” interaction hypothesis of drug hepatotoxicity and provides experimental reference for clinical safe use of green tea-related dietary supplements. Frontiers Media S.A. 2021-01-29 /pmc/articles/PMC7878556/ /pubmed/33584288 http://dx.doi.org/10.3389/fphar.2020.609378 Text en Copyright © 2021 Shi, Zhu, Guo, Niu, Zhang, Tu, Huang, Li, Zhao, Zhang, Bai, Zhang, Lu, Xiao and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Shi, Zhuo
Zhu, Jing-xiao
Guo, Yu-ming
Niu, Ming
Zhang, Le
Tu, Can
Huang, Ying
Li, Peng-yan
Zhao, Xu
Zhang, Zi-teng
Bai, Zhao-fang
Zhang, Guang-qin
Lu, Yang
Xiao, Xiao-he
Wang, Jia-bo
Epigallocatechin Gallate During Dietary Restriction — Potential Mechanisms of Enhanced Liver Injury
title Epigallocatechin Gallate During Dietary Restriction — Potential Mechanisms of Enhanced Liver Injury
title_full Epigallocatechin Gallate During Dietary Restriction — Potential Mechanisms of Enhanced Liver Injury
title_fullStr Epigallocatechin Gallate During Dietary Restriction — Potential Mechanisms of Enhanced Liver Injury
title_full_unstemmed Epigallocatechin Gallate During Dietary Restriction — Potential Mechanisms of Enhanced Liver Injury
title_short Epigallocatechin Gallate During Dietary Restriction — Potential Mechanisms of Enhanced Liver Injury
title_sort epigallocatechin gallate during dietary restriction — potential mechanisms of enhanced liver injury
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878556/
https://www.ncbi.nlm.nih.gov/pubmed/33584288
http://dx.doi.org/10.3389/fphar.2020.609378
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