Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias

The M(1) and M(4) muscarinic acetylcholine receptors (mAChRs) are highly pursued drug targets for neurological diseases, in particular for Alzheimer’s disease and schizophrenia. Due to high sequence homology, selective targeting of any of the M(1)-M(5) mAChRs through the endogenous ligand binding si...

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Detalles Bibliográficos
Autores principales: van der Westhuizen, Emma T., Choy, K. H. Christopher, Valant, Celine, McKenzie-Nickson, Simon, Bradley, Sophie J., Tobin, Andrew B., Sexton, Patrick M., Christopoulos, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878563/
https://www.ncbi.nlm.nih.gov/pubmed/33584282
http://dx.doi.org/10.3389/fphar.2020.606656

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878563/
https://www.ncbi.nlm.nih.gov/pubmed/33584282
http://dx.doi.org/10.3389/fphar.2020.606656

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