Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective

Temporomandibular joint disorders (TMD) are a common health condition caused by the structural or functional disorders of masticatory muscles and the temporomandibular joint (TMJ). Abnormal mandibular movement in TMD patients may cause pain, chronic inflammation, and other discomfort, which could be...

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Detalles Bibliográficos
Autores principales: Wu, Mengjie, Cai, Jingyi, Yu, Yeke, Hu, Sihui, Wang, Yingnan, Wu, Mengrui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878564/
https://www.ncbi.nlm.nih.gov/pubmed/33584275
http://dx.doi.org/10.3389/fphar.2020.596099
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author Wu, Mengjie
Cai, Jingyi
Yu, Yeke
Hu, Sihui
Wang, Yingnan
Wu, Mengrui
author_facet Wu, Mengjie
Cai, Jingyi
Yu, Yeke
Hu, Sihui
Wang, Yingnan
Wu, Mengrui
author_sort Wu, Mengjie
collection PubMed
description Temporomandibular joint disorders (TMD) are a common health condition caused by the structural or functional disorders of masticatory muscles and the temporomandibular joint (TMJ). Abnormal mandibular movement in TMD patients may cause pain, chronic inflammation, and other discomfort, which could be relieved by a variety of drugs through various delivery systems. In this study, we summarized commonly used therapeutic agents in the management of TMD as well as novel bioactive molecules in preclinical stage and clinical trials. The emerging therapy strategies such as novel intra-TMJ delivery systems and implants based on tissue engineering are also discussed. This comprehensive review will strengthen our understanding of pharmacological approaches for TMD therapy.
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spelling pubmed-78785642021-02-13 Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective Wu, Mengjie Cai, Jingyi Yu, Yeke Hu, Sihui Wang, Yingnan Wu, Mengrui Front Pharmacol Pharmacology Temporomandibular joint disorders (TMD) are a common health condition caused by the structural or functional disorders of masticatory muscles and the temporomandibular joint (TMJ). Abnormal mandibular movement in TMD patients may cause pain, chronic inflammation, and other discomfort, which could be relieved by a variety of drugs through various delivery systems. In this study, we summarized commonly used therapeutic agents in the management of TMD as well as novel bioactive molecules in preclinical stage and clinical trials. The emerging therapy strategies such as novel intra-TMJ delivery systems and implants based on tissue engineering are also discussed. This comprehensive review will strengthen our understanding of pharmacological approaches for TMD therapy. Frontiers Media S.A. 2021-01-29 /pmc/articles/PMC7878564/ /pubmed/33584275 http://dx.doi.org/10.3389/fphar.2020.596099 Text en Copyright © 2021 Wu, Cai, Yu, Hu, Wang and Wu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Wu, Mengjie
Cai, Jingyi
Yu, Yeke
Hu, Sihui
Wang, Yingnan
Wu, Mengrui
Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective
title Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective
title_full Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective
title_fullStr Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective
title_full_unstemmed Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective
title_short Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective
title_sort therapeutic agents for the treatment of temporomandibular joint disorders: progress and perspective
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878564/
https://www.ncbi.nlm.nih.gov/pubmed/33584275
http://dx.doi.org/10.3389/fphar.2020.596099
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