A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry

The global spread of SARS-CoV-2 is posing major public health challenges. One feature of SARS-CoV-2 spike protein is the insertion of multi-basic residues at the S1/S2 subunit cleavage site. Here, we find that the virus with intact spike (Sfull) preferentially enters cells via fusion at the plasma m...

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Detalles Bibliográficos
Autores principales: Zhu, Yunkai, Feng, Fei, Hu, Gaowei, Wang, Yuyan, Yu, Yin, Zhu, Yuanfei, Xu, Wei, Cai, Xia, Sun, Zhiping, Han, Wendong, Ye, Rong, Qu, Di, Ding, Qiang, Huang, Xinxin, Chen, Hongjun, Xie, Youhua, Cai, Qiliang, Yuan, Zhenghong, Zhang, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878750/
https://www.ncbi.nlm.nih.gov/pubmed/33574281
http://dx.doi.org/10.1038/s41467-021-21213-4

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