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Spontaneous and frequent conformational dynamics induced by A…A mismatch in d(CAA)·d(TAG) duplex

Base pair mismatches in DNA can erroneously be incorporated during replication, recombination, etc. Here, the influence of A…A mismatch in the context of 5′CAA·5′TAG sequence is explored using molecular dynamics (MD) simulation, umbrella sampling MD, circular dichroism (CD), microscale thermophoresi...

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Detalles Bibliográficos
Autores principales:	Ajjugal, Yogeeshwar, Tomar, Kripi, Rao, D. Krishna, Rathinavelan, Thenmalarchelvi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878774/ https://www.ncbi.nlm.nih.gov/pubmed/33574412 http://dx.doi.org/10.1038/s41598-021-82669-4

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