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Smad4 regulates the nuclear translocation of Nkx2-5 in cardiac differentiation

Bmp plays an important role in cardiomyocyte differentiation, but the function of Smad4 in Bmp signaling remains elusive. Here, we show that disruption of the Smad4 gene in cardiac progenitors expressing Sfrp5 led to embryonic lethality with hypoplastic heart formation. Although the expression of Nk...

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Detalles Bibliográficos
Autores principales:	Hu, Wenyu, Dong, Anqi, Karasaki, Kohei, Sogabe, Shota, Okamoto, Daiki, Saigo, Masato, Ishida, Mari, Yoshizumi, Masao, Kokubo, Hiroki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878807/ https://www.ncbi.nlm.nih.gov/pubmed/33574455 http://dx.doi.org/10.1038/s41598-021-82954-2

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