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Structural mechanism of bivalent histone H3K4me3K9me3 recognition by the Spindlin1/C11orf84 complex in rRNA transcription activation
Spindlin1 is a unique multivalent epigenetic reader that facilitates ribosomal RNA transcription. In this study, we provide molecular and structural basis by which Spindlin1 acts in complex with C11orf84 to preferentially recognize non-canonical bivalent mark of trimethylated lysine 4 and lysine 9 p...
Autores principales: | Du, Yongming, Yan, Yinxia, Xie, Si, Huang, Hao, Wang, Xin, Ng, Ray Kit, Zhou, Ming-Ming, Qian, Chengmin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878818/ https://www.ncbi.nlm.nih.gov/pubmed/33574238 http://dx.doi.org/10.1038/s41467-021-21236-x |
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